Calcium, magnesium and zinc ion coordination equilibria of vincristine

K. Burger, M. Véber, P. Sipos, Z. Galbács, I. Horváth, G. Szepesi, G. Takácsi Nagy, J. Siemroth

Research output: Contribution to journalArticle

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Abstract

The zinc ion coordination of vincristine was studied by polarography; the analogous calcium ion coordination process was studied potentiometrically by a calcium ion selective electrode. In both cases, complexes of 1:1 composition were formed. The formation constant of the calcium complex was found to be 1g K = 3.27 ± 0.1. On the basis of the substitution of zinc in its vincristine complex by calcium and magnesium ions respectively, the ratio of the corresponding stability constants could be estimated as KZn:KCa (and KZn:KMg) ∼ 105-3 × 104. The complex formation processes proved to be pH-independent in the pH range 3.4-5.5, indicating that the metal ions are coordinated by the unprotonated oxygen donor atoms of vincristine.

Original languageEnglish
Pages (from-to)175-179
Number of pages5
JournalInorganica Chimica Acta
Volume124
Issue number4
DOIs
Publication statusPublished - 1986

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Vincristine
Magnesium
magnesium
Zinc
calcium
Calcium
zinc
Ions
ions
polarography
Polarography
ion selective electrodes
Ion-Selective Electrodes
Ion selective electrodes
Polarographic analysis
Metal ions
metal ions
Substitution reactions
Metals
substitutes

ASJC Scopus subject areas

  • Biochemistry
  • Inorganic Chemistry
  • Physical and Theoretical Chemistry
  • Materials Chemistry

Cite this

Burger, K., Véber, M., Sipos, P., Galbács, Z., Horváth, I., Szepesi, G., ... Siemroth, J. (1986). Calcium, magnesium and zinc ion coordination equilibria of vincristine. Inorganica Chimica Acta, 124(4), 175-179. https://doi.org/10.1016/S0020-1693(00)83288-0

Calcium, magnesium and zinc ion coordination equilibria of vincristine. / Burger, K.; Véber, M.; Sipos, P.; Galbács, Z.; Horváth, I.; Szepesi, G.; Nagy, G. Takácsi; Siemroth, J.

In: Inorganica Chimica Acta, Vol. 124, No. 4, 1986, p. 175-179.

Research output: Contribution to journalArticle

Burger, K, Véber, M, Sipos, P, Galbács, Z, Horváth, I, Szepesi, G, Nagy, GT & Siemroth, J 1986, 'Calcium, magnesium and zinc ion coordination equilibria of vincristine', Inorganica Chimica Acta, vol. 124, no. 4, pp. 175-179. https://doi.org/10.1016/S0020-1693(00)83288-0
Burger, K. ; Véber, M. ; Sipos, P. ; Galbács, Z. ; Horváth, I. ; Szepesi, G. ; Nagy, G. Takácsi ; Siemroth, J. / Calcium, magnesium and zinc ion coordination equilibria of vincristine. In: Inorganica Chimica Acta. 1986 ; Vol. 124, No. 4. pp. 175-179.
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