Calcium in the pathomechanism of amyotrophic lateral sclerosis – Taking center stage?

Roland Patai, Bernát Nógrádi, J. Engelhardt, László Siklós

Research output: Contribution to journalReview article

7 Citations (Scopus)

Abstract

Amyotrophic lateral sclerosis is an incurable, relentlessly progressive disease primarily affecting motor neurons. The cause of the disease, except for the mutations identified in a small fraction of patients, is unknown. The major mechanisms contributing to the degeneration of motor neurons have already been disclosed and characterized, including excitotoxicity, oxidative stress, mitochondrial dysfunction, and immune/inflammatory processes. During the progression of the disease these toxic processes are not discrete, but each facilitates the deleterious effect of the other. However, due to their common reciprocal calcium dependence, calcium ions may act as a common denominator and through a positive feedback loop may combine the individual pathological processes into a unified escalating mechanism of neuronal destruction. This mini-review provides an overview of the mutual calcium dependence of the major toxic mechanisms associated with amyotrophic lateral sclerosis.

Original languageEnglish
Pages (from-to)1031-1039
Number of pages9
JournalBiochemical and Biophysical Research Communications
Volume483
Issue number4
DOIs
Publication statusPublished - Feb 19 2017

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Keywords

  • AMPA receptor
  • Amyotrophic lateral sclerosis
  • Calcium
  • Calcium buffering
  • Motor neuron
  • Toxicity

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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