Calcium Handling Defects and Cardiac Arrhythmia Syndromes

Kornél Kistamás, Roland Veress, Balázs Horváth, Tamás Bányász, Péter P. Nánási, David A. Eisner

Research output: Contribution to journalReview article

Abstract

Calcium ions (Ca2+) play a major role in the cardiac excitation-contraction coupling. Intracellular Ca2+ concentration increases during systole and falls in diastole thereby determining cardiac contraction and relaxation. Normal cardiac function also requires perfect organization of the ion currents at the cellular level to drive action potentials and to maintain action potential propagation and electrical homogeneity at the tissue level. Any imbalance in Ca2+ homeostasis of a cardiac myocyte can lead to electrical disturbances. This review aims to discuss cardiac physiology and pathophysiology from the elementary membrane processes that can cause the electrical instability of the ventricular myocytes through intracellular Ca2+ handling maladies to inherited and acquired arrhythmias. Finally, the paper will discuss the current therapeutic approaches targeting cardiac arrhythmias.

Original languageEnglish
Article number72
JournalFrontiers in Pharmacology
Volume11
DOIs
Publication statusPublished - Feb 25 2020

Keywords

  • atrial fibrillation
  • calcium signalling
  • cardiac arrhythmias
  • catecholaminergic polymorphic ventricular tachycardia
  • delayed afterdepolarization
  • early afterdepolarization
  • long QT syndrome
  • reentry

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

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  • Cite this

    Kistamás, K., Veress, R., Horváth, B., Bányász, T., Nánási, P. P., & Eisner, D. A. (2020). Calcium Handling Defects and Cardiac Arrhythmia Syndromes. Frontiers in Pharmacology, 11, [72]. https://doi.org/10.3389/fphar.2020.00072