Calcium dobesilate (Doxium) as a prostaglandin synthetase inhibitor in pregnant human myometrium in vitro

G. Falkay, L. Kovács

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

This comparative study on the effect of calcium dobesilate and indomethacin on prostaglandin biosynthesis was performed on microsomal fractions of pregnant human myometrium. Both drugs inhibited prostaglandin synthesis, indomethacin being more potent. Calcium dobesilate inhibited, in a dose-dependent manner, the synthesis of 6-oxo-PGF, PGF, PGE2 and TXB2. Its inhibitory action is comparable to that of etamsylate.

Original languageEnglish
Pages (from-to)190-191
Number of pages2
JournalExperientia
Volume40
Issue number2
DOIs
Publication statusPublished - Feb 1984

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Calcium Dobesilate
Prostaglandin Antagonists
Myometrium
Prostaglandin-Endoperoxide Synthases
Indomethacin
Prostaglandins
Ethamsylate
Dinoprost
Biosynthesis
Dinoprostone
Pharmaceutical Preparations
In Vitro Techniques

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Calcium dobesilate (Doxium) as a prostaglandin synthetase inhibitor in pregnant human myometrium in vitro. / Falkay, G.; Kovács, L.

In: Experientia, Vol. 40, No. 2, 02.1984, p. 190-191.

Research output: Contribution to journalArticle

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