Calcium-dependent interactions between multivalent ligands and IgM Fc receptors of rat peritoneal macrophages

Research output: Contribution to journalArticle

Abstract

The mechanism of Ca++ dependence of rat peritoneal macrophage IgM-Fc receptor activity was examined. We found that both cell surface bound and intracellular free Ca++ play an important role in the interactions between multivalent IgM complexes and macrophages. On the other hand, Ca++ is not required for binding of native IgM molecules by macrophages. These data support the concept that the IgM-Fc receptor cluster formation itself rather than the receptor - IgM Fc interaction is Ca++ dependent.

Original languageEnglish
Pages (from-to)1189-1192
Number of pages4
JournalMolecular Immunology
Volume19
Issue number9
DOIs
Publication statusPublished - Sep 1982

ASJC Scopus subject areas

  • Immunology
  • Molecular Biology

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