Calcium antagonists prevent early post-infarction ventricular fibrillation

Olu Fagbemi, James R. Parratt

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

The intravenous administration of either nifedipine (in doses of 5-50 μg/kg), niludipine (10 and 50 μg/kg) or nisoldipine (5-1 000 μg/kg) markedly reduced, or abolished, the serious ventricular arrhythmias (tachycardia and fibrillation) that result from acute coronary artery ligation in pentobarbitone-anaesthetized rats. Ventricular ectopic activity, which is pronounced in the first 30 min post-ligation period in this model, was also significantly decreased by nifedipine and niludipine (10 and 50 μg/kg) and by the highest dose (1 mg/kg) of nisoldipine. These results demonstrate the marked efficacy of these three calcium antagonists in this experimental model and raise the possibility that, if given prophylactically, they might reduce the incidence of sudden cardiac death following re-infarction in patients.

Original languageEnglish
Pages (from-to)179-185
Number of pages7
JournalEuropean Journal of Pharmacology
Volume75
Issue number4
DOIs
Publication statusPublished - Nov 5 1981

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Keywords

  • Calcium antagonists
  • Nifedipine
  • Niludipine
  • Nisoldipine
  • Sudden cardiac death
  • Ventricular fibrillation

ASJC Scopus subject areas

  • Pharmacology

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