Calcium and mitochondrial reactive oxygen species generation

How to read the facts

V. Ádám-Vizi, Anatoly A. Starkov

Research output: Contribution to journalArticle

111 Citations (Scopus)

Abstract

A number of recent discoveries indicate that abnormal Ca2+ signaling, oxidative stress, and mitochondrial dysfunction are involved in the neuronal damage in Alzheimer's disease. However, the literature on the interactions between these factors is controversial especially in the interpretation of the cause-effect relationship between mitochondrial damage induced by Ca2+ overload and the production of reactive oxygen species (ROS). In this review, we survey the experimental observations on the Ca2+-induced mitochondrial ROS production, explain the sources of controversy in interpreting these results, and discuss the different molecular mechanisms underlying the effect of Ca2+ on the ROS emission by brain mitochondria.

Original languageEnglish
JournalJournal of Alzheimer's Disease
Volume20
Issue numberSUPPL.2
DOIs
Publication statusPublished - 2010

Fingerprint

Reactive Oxygen Species
Calcium
Alzheimer Disease
Mitochondria
Oxidative Stress
Brain
Surveys and Questionnaires

Keywords

  • Calcium
  • mitochondria
  • permeability transition
  • reactive oxygen species

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Geriatrics and Gerontology
  • Clinical Psychology

Cite this

Calcium and mitochondrial reactive oxygen species generation : How to read the facts. / Ádám-Vizi, V.; Starkov, Anatoly A.

In: Journal of Alzheimer's Disease, Vol. 20, No. SUPPL.2, 2010.

Research output: Contribution to journalArticle

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