Calcaneous quantitative ultrasound measurements predicts vertebral fractures in idiopathic male osteoporosis

Szilvia Mészáros, Edit Tóth, Viktória Ferencz, Emõke Csupor, Éva Hosszú, C. Horváth

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Objectives: The aim of this study was to identify the differences in ultrasound bone variables (QUS) and to test the ability to discriminate male patients with and without vertebral fractures. Methods: We therefore measured broadband ultrasound attenuation (BUA) and speed of sound (SOS) matched for bone mineral density (BMD) and vertebral deformity in idiopathic male osteoporosis. Results: One hundred and seventeen men (age 56.6 range 27-78) were divided into three groups (osteoporosis n = 25, osteopenia n = 58 and age-matched control n = 34) according to BMD T-score by WHO criteria. We found 66 patients (56%) with at least one vertebral deformity during the study. BMD and BUA did not differ, while SOS was lower in osteoporosis (p <0.001) and control group (p <0.001) between the patients with and without vertebral compression. Strong positive correlation was demonstrated between BUA and BMD (lumbar spine r = 0.44, p <0.001, femoral neck r = 0.56, p <0.001, radius r = 0.40, p <0.001), while similar association between SOS and BMD values was not shown. There was no relationship between the BUA and vertebral fracture risk (Odds ratio: 1.14 95% CI: 0.80-1.61). However, the relative risk of vertebral fracture by SOS was 1.56 (95% CI: 1.08-2.62). Adjusting for age and BMI the risk of vertebral fracture did not change (odds ratio for SOS 1.50 95% CI: 1.02-2.22). After adjustment for BMD SOS was still associated with fracture risk at all measured sites (odds ratio: 1.43, 95% CI: 1.02-2.22; 1.41, 95% CI: 1.02-2.17 and 1.32, 95% CI: 1.02-2.0). Conclusion: Our results suggest that BUA values are more closely related to density and structure while SOS values are able to predict fractures.

Original languageEnglish
Pages (from-to)79-84
Number of pages6
JournalJoint Bone Spine
Volume74
Issue number1
DOIs
Publication statusPublished - Jan 2007

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Osteoporosis
Bone Density
Odds Ratio
Metabolic Bone Diseases
Femur Neck
Spine
Bone and Bones
Control Groups

Keywords

  • Bone quantitative ultrasound
  • Male osteoporosis
  • Vertebral fracture risk

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine

Cite this

Calcaneous quantitative ultrasound measurements predicts vertebral fractures in idiopathic male osteoporosis. / Mészáros, Szilvia; Tóth, Edit; Ferencz, Viktória; Csupor, Emõke; Hosszú, Éva; Horváth, C.

In: Joint Bone Spine, Vol. 74, No. 1, 01.2007, p. 79-84.

Research output: Contribution to journalArticle

Mészáros, Szilvia ; Tóth, Edit ; Ferencz, Viktória ; Csupor, Emõke ; Hosszú, Éva ; Horváth, C. / Calcaneous quantitative ultrasound measurements predicts vertebral fractures in idiopathic male osteoporosis. In: Joint Bone Spine. 2007 ; Vol. 74, No. 1. pp. 79-84.
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AB - Objectives: The aim of this study was to identify the differences in ultrasound bone variables (QUS) and to test the ability to discriminate male patients with and without vertebral fractures. Methods: We therefore measured broadband ultrasound attenuation (BUA) and speed of sound (SOS) matched for bone mineral density (BMD) and vertebral deformity in idiopathic male osteoporosis. Results: One hundred and seventeen men (age 56.6 range 27-78) were divided into three groups (osteoporosis n = 25, osteopenia n = 58 and age-matched control n = 34) according to BMD T-score by WHO criteria. We found 66 patients (56%) with at least one vertebral deformity during the study. BMD and BUA did not differ, while SOS was lower in osteoporosis (p <0.001) and control group (p <0.001) between the patients with and without vertebral compression. Strong positive correlation was demonstrated between BUA and BMD (lumbar spine r = 0.44, p <0.001, femoral neck r = 0.56, p <0.001, radius r = 0.40, p <0.001), while similar association between SOS and BMD values was not shown. There was no relationship between the BUA and vertebral fracture risk (Odds ratio: 1.14 95% CI: 0.80-1.61). However, the relative risk of vertebral fracture by SOS was 1.56 (95% CI: 1.08-2.62). Adjusting for age and BMI the risk of vertebral fracture did not change (odds ratio for SOS 1.50 95% CI: 1.02-2.22). After adjustment for BMD SOS was still associated with fracture risk at all measured sites (odds ratio: 1.43, 95% CI: 1.02-2.22; 1.41, 95% CI: 1.02-2.17 and 1.32, 95% CI: 1.02-2.0). Conclusion: Our results suggest that BUA values are more closely related to density and structure while SOS values are able to predict fractures.

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