Caerulein stimulates pancreatic secretory response in conscious newborn rats

Miklós Papp, David A. Dreiling, István Dobronyi, G. Varga

Research output: Contribution to journalArticle

Abstract

The aim of our study was to measure age-dependent, caerulein-stimulated pancreatic enzyme secretion of conscious CFY suckling rats without pancreatic duct cannulation. Pancreatic secretory response was expressed as the decrease in specific enzyme (trypsin, amylase) activity compared to saline-injected control. The study was performed in three phases. In 10-d-old conscious newborn rats, single 1 and 3 ug/kg sc doses of caerulein induced significant decreases in specific trypsin (42 and 47 %) and amylase (34 and 33%) activity 15 min after the caerulein injection; the same doses injected at 0 and 30 min evoked a similar decrease 90 min after the first injection. The 0.5 μg/kg dose was ineffective. In 10-d-old anesthetized rats, the 90-min-decrease in total pancreatic trypsin activity, induced by graded doses (1,3,10, and 30 μ/kg) of caerulein, was compared to the 90-min output of trypsin in their bile-pancreatic juice. Each of the applied doses induced significant change in the total trypsin activity both in the pancreas (-33-57%) and juice (+ 21 ±49%) and its decrease in the gland corresponded quantitatively well (r = 0,52; p

Original languageEnglish
Pages (from-to)161-174
Number of pages14
JournalInternational Journal of Pancreatology
Volume4
Issue number2
DOIs
Publication statusPublished - Mar 1989

Fingerprint

Ceruletide
Trypsin
Amylases
Pancreatic Juice
Injections
Pancreatic Ducts
Enzymes
Bile
Catheterization
Pancreas

Keywords

  • amylase
  • Careulein
  • development
  • pancreas
  • trypsin

ASJC Scopus subject areas

  • Oncology
  • Gastroenterology
  • Endocrinology

Cite this

Caerulein stimulates pancreatic secretory response in conscious newborn rats. / Papp, Miklós; Dreiling, David A.; Dobronyi, István; Varga, G.

In: International Journal of Pancreatology, Vol. 4, No. 2, 03.1989, p. 161-174.

Research output: Contribution to journalArticle

Papp, Miklós ; Dreiling, David A. ; Dobronyi, István ; Varga, G. / Caerulein stimulates pancreatic secretory response in conscious newborn rats. In: International Journal of Pancreatology. 1989 ; Vol. 4, No. 2. pp. 161-174.
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