C3b Acceptors on macrophages: Inhibition of Fcγ-receptor-mediated phagocytosis by acceptor-bound C3b

Zsuzsa Fábry, Anna Erdei, János Gergely

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The binding of nascent human C3b (i.e. the fragment of C3 just after trypsin cleavage) to mouse peritoneal macrophages was demonstrated by immune adherence. Acceptor-bound C3b could be detected longer than 24 h on the cell membrane. The rosette formation and phagocytosis of SRBC coated with anti-SRBC rat IgG was inhibited by preincubation of the cells with C3 and trypsin (15 min, 37°C). However, the phagocytosis of opsonized yeast particles was not influenced by acceptor-bound C3b, proving that C3bC3b acceptor interaction did not alter the function of C3b-receptors. Acceptor-bound C3b on the macrophages failed to mediate phagocytosis of human 0,Rh+ red cells having C3b-receptors.

Original languageEnglish
Pages (from-to)287-291
Number of pages5
JournalImmunology letters
Volume6
Issue number6
DOIs
Publication statusPublished - Jun 1983

Keywords

  • C3b acceptor FcγR-inhibition - peritoneal exudate cells immune adherence

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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