c-myc, c-erbb-2, c-fms and bcl-2 Oncoproteins

Expression in normal placenta, partial and complete mole, and choriocarcinoma

V. Fülöp, Samuel C. Mok, David R. Genest, Ivan Szigetvari, Imre Cseh, Ross S. Berkowitz

Research output: Contribution to journalArticle

66 Citations (Scopus)

Abstract

OBJECTIVE: To determine the expression of bcl-2, c-myc, c-fms and c- erbB-2 oncoproteins in normal placentas, partial and complete hydatidiform moles, and choriocarcinomas and to examine the possible presence of mutations in the K-ras gene in complete moles and choriocarcinomas. STUDY DESIGN: The expression of the above oncoproteins was determined immunohistochemically by specific antibodies for these proteins on formalin-fixed paraffin sections of 18 normal placentas, 17 partial moles, 25 complete moles and 11 choriocarcinomas. This was followed by polymerase chain reaction analysis (exons 12 and 13) of K-ras gene for possible mutations in complete moles and choriocarcinomas. RESULTS: Expression of c fms oncoprotein appeared confined to the cytoplasm of syncytiotrophoblastic cells. The c-fms protein staining intensity of the syncytiotrophoblastic layer showed no significant difference among the four gestational tissues. c-erbB-2 antibody expression was confined to the cellular membrane of the extravillous trophoblast. When compared with normal placenta or partial mole, the expression of c-erbB-2 protein was significantly stronger in complete mole (P

Original languageEnglish
Pages (from-to)101-110
Number of pages10
JournalJournal of Reproductive Medicine for the Obstetrician and Gynecologist
Volume43
Issue number2
Publication statusPublished - Feb 1998

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Choriocarcinoma
Oncogene Proteins
Placenta
Hydatidiform Mole
ras Genes
Macrophage Colony-Stimulating Factor Receptors
ErbB-2 Receptor
Mutation
Antibodies
Trophoblasts
Paraffin
Formaldehyde
Exons
Cytoplasm
Staining and Labeling
Polymerase Chain Reaction
Membranes
Proteins

Keywords

  • Choriocarcinoma
  • Mole
  • Oncoproteins
  • Ras genes

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Reproductive Medicine

Cite this

c-myc, c-erbb-2, c-fms and bcl-2 Oncoproteins : Expression in normal placenta, partial and complete mole, and choriocarcinoma. / Fülöp, V.; Mok, Samuel C.; Genest, David R.; Szigetvari, Ivan; Cseh, Imre; Berkowitz, Ross S.

In: Journal of Reproductive Medicine for the Obstetrician and Gynecologist, Vol. 43, No. 2, 02.1998, p. 101-110.

Research output: Contribution to journalArticle

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