C-myc amplification and cluster analysis in human gastric carcinoma

L. Kozma, I. Kiss, J. Hajdú, Z. Szentkereszty, S. Szakáll, I. Ember

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

The tumour samples of 23 patients (9 male, 14 female, aged 28-85) were randomly selected for the study. DNA was isolated from paraffin embedded tissue for quantitative dot-blot hybridization, in order to determine the amplification values for the c-myc and K-fas oncogenes. The clinical and histological parameters studied were as follows: grade, TNM staging system, Lauren's histological type, localization and the severity of the disease. Amplified c-myc was found in 6 cases. Amplification was concomitant with c-myc overexpression detected with immunohistochemical staining. The amplification - 9.1-fold on the average (ranging from 2.12 to 18.2) was significantly associated with the presence of distant metastasis (corr. coeff.: 0.5623, p

Original languageEnglish
Pages (from-to)707-710
Number of pages4
JournalAnticancer Research
Volume21
Issue number1 B
Publication statusPublished - 2001

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Neoplasm Staging
Oncogenes
Paraffin
Cluster Analysis
Stomach
Staining and Labeling
Neoplasm Metastasis
Carcinoma
DNA
Neoplasms

Keywords

  • Age
  • Amplification
  • C-myc
  • Cluster
  • Gastric cancer
  • K-ras
  • Progression

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Kozma, L., Kiss, I., Hajdú, J., Szentkereszty, Z., Szakáll, S., & Ember, I. (2001). C-myc amplification and cluster analysis in human gastric carcinoma. Anticancer Research, 21(1 B), 707-710.

C-myc amplification and cluster analysis in human gastric carcinoma. / Kozma, L.; Kiss, I.; Hajdú, J.; Szentkereszty, Z.; Szakáll, S.; Ember, I.

In: Anticancer Research, Vol. 21, No. 1 B, 2001, p. 707-710.

Research output: Contribution to journalArticle

Kozma, L, Kiss, I, Hajdú, J, Szentkereszty, Z, Szakáll, S & Ember, I 2001, 'C-myc amplification and cluster analysis in human gastric carcinoma', Anticancer Research, vol. 21, no. 1 B, pp. 707-710.
Kozma, L. ; Kiss, I. ; Hajdú, J. ; Szentkereszty, Z. ; Szakáll, S. ; Ember, I. / C-myc amplification and cluster analysis in human gastric carcinoma. In: Anticancer Research. 2001 ; Vol. 21, No. 1 B. pp. 707-710.
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