Burkholderia cepacia lipase is an excellent enzyme for the enantioselective hydrolysis of β-heteroaryl-β-amino esters

Gábor Tasnádi, Eniko Forró, Ferenc Fülöp

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

The enantioselective (E >200) lipase PS-catalysed hydrolysis of β-heteroaryl-β-amino esters is described. The reactions were performed with H2O (0.5 equiv) in either diisopropyl ether or tert-butyl methyl ether at 25 °C. The resulting β-heteroaryl-substituted β-amino acid enantiomers were formed in high enantiomeric excess (ee ≥ 97%) and in good yield (≥40%).

Original languageEnglish
Pages (from-to)1771-1777
Number of pages7
JournalTetrahedron Asymmetry
Volume20
Issue number15
DOIs
Publication statusPublished - Aug 12 2009

ASJC Scopus subject areas

  • Catalysis
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

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