BSA-anti-BSA immune complexes formed in the presence of human complement do not bind to autologous red blood cells

L. Varga, E. Thiry, G. Füst

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Abstract

The binding of 125I-BSA-anti-BSA immune complexes (IC) formed in the presence of complement (nascent IC) and those that reacted with complement after their formation (preformed IC) to human erythrocytes was studied. The effect of antigen-antibody ratios and serum dilutions on IC binding to red blood cells (RBC) were also investigated. A dramatic difference was found between the behaviour of the two types of complexes: while preformed IC bound effectively to human RBC after their interaction with complement, no efficient RBC-binding was observed with nascent BSA-anti-BSA complexes formed in the presence of complement. Changing the antigen-antibody ratio or dilution of serum did not affect markedly the extent of difference between the binding of preformed and nascent IC. Our findings do not support the essential role of red blood cells in the elimination of each type of IC.

Original languageEnglish
Pages (from-to)381-384
Number of pages4
JournalImmunology
Volume64
Issue number3
Publication statusPublished - 1988

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Antigen-Antibody Complex
Erythrocytes
Antigens
Antibodies
Serum

ASJC Scopus subject areas

  • Immunology

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BSA-anti-BSA immune complexes formed in the presence of human complement do not bind to autologous red blood cells. / Varga, L.; Thiry, E.; Füst, G.

In: Immunology, Vol. 64, No. 3, 1988, p. 381-384.

Research output: Contribution to journalArticle

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