Brown cornea

Zita Steiber, Niels Ehlers, Steffen Heegaard, Jesper Hjortdal, A. Berta, Jan Ulrik Prause

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background: A brown cornea is relatively rare. We report a case of progressive brown corneal pigmentation in a patient with a primary acquired melanosis of the conjunctiva. Later the patient developed an iris melanoma. Methods: Case report with clinico-pathological correlation and discussion of possible mechanisms of particle clearance of the cornea. Results: A 36-year-old female developed a corneal stromal pigmentation adjacent to a pigmented conjunctival lesion of the left eye. The corneal pigmentation had progressed through 8 years. The conjunctival lesion was surgically removed, and proved histopathologically to be a compound nevus with slight atypia and an acquired melanosis. Despite surgery the corneal pigmentation increased, and visual acuity dropped in the diseased eye. A perforating keratoplasty was performed, and two small pigmented iris nodules were now noted. Three years after grafting, growth of the two iris tumours was obvious. In addition, pigmentation of the trabecular meshwork and large, pigmented endothelial precipitates were observed. The corneal pigmentation also increased. The eye was enucleated. Histopathologic evaluation demonstrated a marked accumulation of melanophages on the endothelium of the graft. The host cornea contained pigmented cells in the mid-stroma. The iris contained two melanomas. Conclusions: The brown pigmentation of the cornea was due to pigment granules from the iris tumours liberated to the anterior chamber. The pigment was transported into the cornea through the endothelium and accumulated in melanophages between corneal lamellas. The pigment subsequently cleared via the corneal limbus in a process resembling clearance of corneal haemochromatosis.

Original languageEnglish
Pages (from-to)537-541
Number of pages5
JournalGraefe's Archive for Clinical and Experimental Ophthalmology
Volume246
Issue number4
DOIs
Publication statusPublished - Apr 2008

Fingerprint

Pigmentation
Cornea
Iris
Melanosis
Endothelium
Melanoma
Limbus Corneae
Trabecular Meshwork
Corneal Transplantation
Hemochromatosis
Eye Diseases
Nevus
Conjunctiva
Anterior Chamber
Visual Acuity
Neoplasms
Transplants
Growth

Keywords

  • Brown cornea
  • Clearance of pigments
  • Corneal pigmentation
  • Malignant melanoma
  • Particle migration

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Steiber, Z., Ehlers, N., Heegaard, S., Hjortdal, J., Berta, A., & Prause, J. U. (2008). Brown cornea. Graefe's Archive for Clinical and Experimental Ophthalmology, 246(4), 537-541. https://doi.org/10.1007/s00417-007-0736-9

Brown cornea. / Steiber, Zita; Ehlers, Niels; Heegaard, Steffen; Hjortdal, Jesper; Berta, A.; Prause, Jan Ulrik.

In: Graefe's Archive for Clinical and Experimental Ophthalmology, Vol. 246, No. 4, 04.2008, p. 537-541.

Research output: Contribution to journalArticle

Steiber, Z, Ehlers, N, Heegaard, S, Hjortdal, J, Berta, A & Prause, JU 2008, 'Brown cornea', Graefe's Archive for Clinical and Experimental Ophthalmology, vol. 246, no. 4, pp. 537-541. https://doi.org/10.1007/s00417-007-0736-9
Steiber Z, Ehlers N, Heegaard S, Hjortdal J, Berta A, Prause JU. Brown cornea. Graefe's Archive for Clinical and Experimental Ophthalmology. 2008 Apr;246(4):537-541. https://doi.org/10.1007/s00417-007-0736-9
Steiber, Zita ; Ehlers, Niels ; Heegaard, Steffen ; Hjortdal, Jesper ; Berta, A. ; Prause, Jan Ulrik. / Brown cornea. In: Graefe's Archive for Clinical and Experimental Ophthalmology. 2008 ; Vol. 246, No. 4. pp. 537-541.
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