UN ESTRATTO BATTERICO INIBISCE IL RILASCIO DI ISTAMINA INDOTTO DAL COMPOSTO 48/80 E DALLO IONOFORO A23187 NEI MASTOCITI DI TOPO

Translated title of the contribution: Broncho-Vaxom inhibits histamine release from rat mast cells induced by compound 48/80 and ionophore A23187

A. Nemeth, P. Magyar

Research output: Contribution to journalArticle

Abstract

A bacterial extract (BV) inhibited in a dose-dependent manner the release of histamine from and degranulation of isolated rat peritoneal mast cells stimulated with compound 48/80 and the ionophore A23187. Inhibition persisted after removal of BV from the incubation medium before stimulation, but did not occur when bovine serum albumin (BSA) was used instead of BV. Binding of BV to mast cells was observed by electron microscopy on cells that had been incubated with colloidal-gold labelled BV. There was no significant difference between the binding of BV gold and BSA gold to the mast cells. Washing before fixation removed most of the BV gold from the cells. This study establishes BV as an in vitro histamine release inhibitor.

Translated title of the contributionBroncho-Vaxom inhibits histamine release from rat mast cells induced by compound 48/80 and ionophore A23187
Original languageItalian
Pages (from-to)160-162
Number of pages3
JournalGiornale Italiano di Ricerche Cliniche e Terapeutiche
Volume14
Issue number6
Publication statusPublished - Dec 1 1993

Keywords

  • histamine
  • mast cells
  • microscopy

ASJC Scopus subject areas

  • Pharmacology

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