Bronchial carcinoid tumors metastatic to the sella turcica and review of the literature

Olga Moshkin, Fabio Rotondo, Bernd W. Scheithauer, Mark Soares, Claire Coire, Harley S. Smyth, Miklos Goth, Eva Horvath, Kalman Kovacs

Research output: Contribution to journalReview article

9 Citations (Scopus)

Abstract

We review here the literature on neuroendocrine neoplasms metastatic to the pituitary and present an example of the disease. Metastasis of bronchial carcinoid tumors to the sellar region are rare. Herein, we describe the case of a 63-year-old woman who presented with constant cough and headaches. She had previously been operated for carcinoid tumor of the lung. During the preoperative investigation, a CT scan of the head revealed a sellar mass. Six months after a left lower lobectomy, the sellar lesion was removed by transsphenoidal surgery. The two tumors were evaluated by histology, immunohistochemistry and electron microscopy. Both showed identical morphologic features, those of carcinoid tumor. Immunohistochemistry revealed immunoreactivity for the endocrine markers, synaptophysin and chromogranin, as well as CD-56, serotonin, bombesin and vascular endothelial growth factor. The sellar neoplasm showed nuclear immunopositivity for thyroid transcription factor-1, supporting the diagnosis of a metastatic bronchial carcinoid tumor. In conclusion, this is the first report of a serotonin- and bombesin- immunopositive atypical bronchial carcinoid tumor metastatic to the sella.

Original languageEnglish
Pages (from-to)160-165
Number of pages6
JournalPituitary
Volume15
Issue number2
DOIs
Publication statusPublished - Jun 1 2012

Keywords

  • Bronchial carcinoid tumor
  • Electron microscopy
  • Immunohistochemistry
  • Pathology
  • Pituitary metastasis

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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  • Cite this

    Moshkin, O., Rotondo, F., Scheithauer, B. W., Soares, M., Coire, C., Smyth, H. S., Goth, M., Horvath, E., & Kovacs, K. (2012). Bronchial carcinoid tumors metastatic to the sella turcica and review of the literature. Pituitary, 15(2), 160-165. https://doi.org/10.1007/s11102-012-0388-6