Bromocriptine inhibits salsolinol-induced prolactin release in male goats

Tsutomu Hashizume, Tatsuru Sawada, Yuka Nakajima, Tomoyoshi Yaegashi, Hayato Saito, Yuki Goto, Jin Jin, F. Fülöp, György Miklos Nagy

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The secretion of prolactin (PRL) is under the dominant and tonic inhibitory control of dopamine (DA); however, we have recently found that salsolinol (SAL), an endogenous DA-derived compound, strongly stimulated the release of PRL in ruminants. The aim of the present study was to clarify the inhibitory effect of DA on the SAL-induced release of PRL in ruminants. The experiments were performed from late June to early July. Male goats were given a single intravenous (i.v.) injection of SAL (5mg/kg body weight (BW)), a DA receptor antagonist (sulpiride, 0.1mg/kg BW), or thyrotropin-releasing hormone (TRH, 1μg/kg BW) before and after treatment with a DA receptor agonist (bromocriptine), and the effect of DA on SAL-induced PRL release was compared to that on sulpiride- or TRH-induced release. Bromocriptine completely inhibited the SAL-induced release of PRL (P

Original languageEnglish
Pages (from-to)63-67
Number of pages5
JournalAnimal Science Journal
Volume83
Issue number1
DOIs
Publication statusPublished - Jan 2012

Fingerprint

bromocriptine
Bromocriptine
prolactin
Goats
Prolactin
dopamine
goats
Dopamine
Sulpiride
Body Weight
Ruminants
body weight
ruminants
thyrotropin-releasing hormone
Thyrotropin-Releasing Hormone
Dopamine Antagonists
Dopamine Agonists
intravenous injection
Intravenous Injections
agonists

Keywords

  • Bromocriptine
  • Dopamine
  • Prolactin
  • Ruminants
  • Salsolinol

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)

Cite this

Hashizume, T., Sawada, T., Nakajima, Y., Yaegashi, T., Saito, H., Goto, Y., ... Nagy, G. M. (2012). Bromocriptine inhibits salsolinol-induced prolactin release in male goats. Animal Science Journal, 83(1), 63-67. https://doi.org/10.1111/j.1740-0929.2011.00914.x

Bromocriptine inhibits salsolinol-induced prolactin release in male goats. / Hashizume, Tsutomu; Sawada, Tatsuru; Nakajima, Yuka; Yaegashi, Tomoyoshi; Saito, Hayato; Goto, Yuki; Jin, Jin; Fülöp, F.; Nagy, György Miklos.

In: Animal Science Journal, Vol. 83, No. 1, 01.2012, p. 63-67.

Research output: Contribution to journalArticle

Hashizume, T, Sawada, T, Nakajima, Y, Yaegashi, T, Saito, H, Goto, Y, Jin, J, Fülöp, F & Nagy, GM 2012, 'Bromocriptine inhibits salsolinol-induced prolactin release in male goats', Animal Science Journal, vol. 83, no. 1, pp. 63-67. https://doi.org/10.1111/j.1740-0929.2011.00914.x
Hashizume T, Sawada T, Nakajima Y, Yaegashi T, Saito H, Goto Y et al. Bromocriptine inhibits salsolinol-induced prolactin release in male goats. Animal Science Journal. 2012 Jan;83(1):63-67. https://doi.org/10.1111/j.1740-0929.2011.00914.x
Hashizume, Tsutomu ; Sawada, Tatsuru ; Nakajima, Yuka ; Yaegashi, Tomoyoshi ; Saito, Hayato ; Goto, Yuki ; Jin, Jin ; Fülöp, F. ; Nagy, György Miklos. / Bromocriptine inhibits salsolinol-induced prolactin release in male goats. In: Animal Science Journal. 2012 ; Vol. 83, No. 1. pp. 63-67.
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