Brightly fluorescent purple and blue labels for amines and proteins

Martin Link, Péter Kele, Daniela E. Achatz, Otto S. Wolfbeis

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Novel amino-reactive phenoxazines were obtained by reasonably simple synthetic protocols and characterized in terms of their use as fluorescent labels for amines, amino acids and proteins in general. Purple labels (alternatives to Texas Red) and blue labels (alternatives to Cy-1) were obtained by this strategy. The absorption/emission maxima, in aqueous solution, are at around 589/630 nm and 648/670 nm, respectively, thus indicating larger Stokes' shifts than those of common cyanine-type of labels. The new labels are compatible with commercial diode laser light sources.

Original languageEnglish
Pages (from-to)5538-5542
Number of pages5
JournalBioorganic and Medicinal Chemistry Letters
Volume21
Issue number18
DOIs
Publication statusPublished - Sep 15 2011

Keywords

  • Amino reactive label
  • Bioconjugation
  • Fluorescent label
  • Oxazine
  • Protein label

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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