Breast milk alkylglycerols sustain beige adipocytes through adipose tissue macrophages

Haidong Yu, Sedat Dilbaz, Jonas Coßmann, Anh Cuong Hoang, Victoria Diedrich, Annika Herwig, Akiko Harauma, Yukino Hoshi, Toru Moriguchi, Kathrin Landgraf, Antje Körner, Christina Lucas, Susanne Brodesser, L. Balogh, Julianna Thuróczy, Gopal Karemore, Michael Scott Kuefner, Edwards A. Park, Christine Rapp, Jeffrey Bryant TraversTamás Röszer

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Prevalence of obesity among infants and children below 5 years of age is rising dramatically, and early childhood obesity is a forerunner of obesity and obesity-associated diseases in adulthood. Childhood obesity is hence one of the most serious public health challenges today. Here, we have identified a mother-to-child lipid signaling that protects from obesity. We have found that breast milk–specific lipid species, so-called alkylglycerol-type (AKG-type) ether lipids, which are absent from infant formula and adult-type diets, maintain beige adipose tissue (BeAT) in the infant and impede the transformation of BeAT into lipid-storing white adipose tissue (WAT). Breast milk AKGs are metabolized by adipose tissue macrophages (ATMs) to platelet-activating factor (PAF), which ultimately activates IL-6/STAT3 signaling in adipocytes and triggers BeAT development in the infant. Accordingly, lack of AKG intake in infancy leads to a premature loss of BeAT and increases fat accumulation. AKG signaling is specific for infants and is inactivated in adulthood. However, in obese adipose tissue, ATMs regain their ability to metabolize AKGs, which reduces obesity. In summary, AKGs are specific lipid signals of breast milk that are essential for healthy adipose tissue development.

Original languageEnglish
Pages (from-to)2485-2499
Number of pages15
JournalJournal of Clinical Investigation
Volume129
Issue number6
DOIs
Publication statusPublished - Jun 3 2019

    Fingerprint

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Yu, H., Dilbaz, S., Coßmann, J., Hoang, A. C., Diedrich, V., Herwig, A., Harauma, A., Hoshi, Y., Moriguchi, T., Landgraf, K., Körner, A., Lucas, C., Brodesser, S., Balogh, L., Thuróczy, J., Karemore, G., Kuefner, M. S., Park, E. A., Rapp, C., ... Röszer, T. (2019). Breast milk alkylglycerols sustain beige adipocytes through adipose tissue macrophages. Journal of Clinical Investigation, 129(6), 2485-2499. https://doi.org/10.1172/JCI125646