Breast cancer under 40 years of age

Increasing number and worse prognosis

Ágnes Dobi, Gyöngyi Kelemen, László Kaizer, Roland Weiczner, L. Thurzó, Z. Kahán

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Breast cancer at a relatively young age with a poor prognosis is currently exhibiting an increasing incidence. In a retrospective cohort analysis of early breast cancer cases after surgery from our institutional patient registry, 141 patients aged ≤40 years constituted the younger group, with 300 randomly selected patients aged >40 years as controls. A significant and steady increase was found in the relative number of younger cases during the years 2004-2009. The histological type and grade and the lymph node status of the cancers differed significantly between the two groups, with more aggressive biological behaviour, a more advanced stage and a worse prognosis in the younger group. Half of the cancers in the younger cohort were ER-negative, while two-thirds in the control group were ER-positive. Comparatively more tumours were PR-positive and HER2-negative in the control group than in the younger group. The rates of triple-negative cases were 25% and 13% in the younger age and the control group, respectively (p=0.026). Significantly higher mastectomy and axillary block dissection rates were observed in the younger age group, and more chemotherapy was administered than in the control group. Our findings demonstrate the significance of breast cancer in cases aged

Original languageEnglish
Pages (from-to)425-428
Number of pages4
JournalPathology and Oncology Research
Volume17
Issue number2
DOIs
Publication statusPublished - Jun 2011

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Breast Neoplasms
Control Groups
Age Groups
Neoplasms
Mastectomy
Registries
Dissection
Cohort Studies
Lymph Nodes
Drug Therapy
Incidence

Keywords

  • Age
  • Breast cancer
  • Incidence
  • Predictive factors
  • Prognostic factors

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Pathology and Forensic Medicine

Cite this

Breast cancer under 40 years of age : Increasing number and worse prognosis. / Dobi, Ágnes; Kelemen, Gyöngyi; Kaizer, László; Weiczner, Roland; Thurzó, L.; Kahán, Z.

In: Pathology and Oncology Research, Vol. 17, No. 2, 06.2011, p. 425-428.

Research output: Contribution to journalArticle

Dobi, Ágnes ; Kelemen, Gyöngyi ; Kaizer, László ; Weiczner, Roland ; Thurzó, L. ; Kahán, Z. / Breast cancer under 40 years of age : Increasing number and worse prognosis. In: Pathology and Oncology Research. 2011 ; Vol. 17, No. 2. pp. 425-428.
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