Breakdown of bioenergetics evoked by mitochondrial damage in acute pancreatitis: Mechanisms and consequences

Research output: Contribution to journalReview article

9 Citations (Scopus)

Abstract

Acute pancreatitis is a severe inflammatory disease with unacceptably high mortality and without specific therapy. Clinical studies revealed that energy supplementation of patients via enteral feeding decreases systemic infections, multi-organ failure and mortality. These clinical observations have been supported by in vitro and in vivo experimental studies which showed that the most common pancreatitis inducing factors, such as bile acids, ethanol and non-oxidative ethanol metabolites induce intracellular ATP depletion and mitochondrial damage both in pancreatic acinar and ductal cells. Notably, the in vitro supplementation of ATP prevented the cellular damage and restored cell functions in both cell types. These observations suggest that either prevention of mitochondrial damage or restoration of intracellular ATP level might provide therapeutical benefits.

Original languageEnglish
Pages (from-to)S18-S22
JournalPancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]
Volume15
Issue number4
DOIs
Publication statusPublished - Jul 1 2015

Fingerprint

Pancreatitis
Energy Metabolism
Adenosine Triphosphate
Ethanol
Mortality
Acinar Cells
Enteral Nutrition
Bile Acids and Salts
Infection
Therapeutics
Clinical Studies

Keywords

  • ATP
  • Bile acids
  • Bioenergetics
  • Ethanol
  • Mitochondria
  • Pancreatitis

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Hepatology
  • Endocrinology

Cite this

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title = "Breakdown of bioenergetics evoked by mitochondrial damage in acute pancreatitis: Mechanisms and consequences",
abstract = "Acute pancreatitis is a severe inflammatory disease with unacceptably high mortality and without specific therapy. Clinical studies revealed that energy supplementation of patients via enteral feeding decreases systemic infections, multi-organ failure and mortality. These clinical observations have been supported by in vitro and in vivo experimental studies which showed that the most common pancreatitis inducing factors, such as bile acids, ethanol and non-oxidative ethanol metabolites induce intracellular ATP depletion and mitochondrial damage both in pancreatic acinar and ductal cells. Notably, the in vitro supplementation of ATP prevented the cellular damage and restored cell functions in both cell types. These observations suggest that either prevention of mitochondrial damage or restoration of intracellular ATP level might provide therapeutical benefits.",
keywords = "ATP, Bile acids, Bioenergetics, Ethanol, Mitochondria, Pancreatitis",
author = "J{\'o}zsef Mal{\'e}th and P. Hegyi and Z. Rakonczay and V. Venglovecz",
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T1 - Breakdown of bioenergetics evoked by mitochondrial damage in acute pancreatitis

T2 - Mechanisms and consequences

AU - Maléth, József

AU - Hegyi, P.

AU - Rakonczay, Z.

AU - Venglovecz, V.

PY - 2015/7/1

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N2 - Acute pancreatitis is a severe inflammatory disease with unacceptably high mortality and without specific therapy. Clinical studies revealed that energy supplementation of patients via enteral feeding decreases systemic infections, multi-organ failure and mortality. These clinical observations have been supported by in vitro and in vivo experimental studies which showed that the most common pancreatitis inducing factors, such as bile acids, ethanol and non-oxidative ethanol metabolites induce intracellular ATP depletion and mitochondrial damage both in pancreatic acinar and ductal cells. Notably, the in vitro supplementation of ATP prevented the cellular damage and restored cell functions in both cell types. These observations suggest that either prevention of mitochondrial damage or restoration of intracellular ATP level might provide therapeutical benefits.

AB - Acute pancreatitis is a severe inflammatory disease with unacceptably high mortality and without specific therapy. Clinical studies revealed that energy supplementation of patients via enteral feeding decreases systemic infections, multi-organ failure and mortality. These clinical observations have been supported by in vitro and in vivo experimental studies which showed that the most common pancreatitis inducing factors, such as bile acids, ethanol and non-oxidative ethanol metabolites induce intracellular ATP depletion and mitochondrial damage both in pancreatic acinar and ductal cells. Notably, the in vitro supplementation of ATP prevented the cellular damage and restored cell functions in both cell types. These observations suggest that either prevention of mitochondrial damage or restoration of intracellular ATP level might provide therapeutical benefits.

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KW - Bile acids

KW - Bioenergetics

KW - Ethanol

KW - Mitochondria

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