Branched polymeric polypeptides with poly[Lys]

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

This chapter is to outline the design, synthesis, chemical and functional characterization of a set of structurally related branched polymeric polypeptides with poly[Lys] backbone. It has been documented that the composition and amino acid sequence of the branch could markedly determine the physico-chemical characteristics including solution conformation, the interaction phospholipid mono- or bilayers as well as the biological properties, like cytotoxicity, blood clearance, biodistribution, immunoreactivity of the compound and even related bioconjugates with chemotherapeutic agent, peptide epitope or reporter entity. The synthesis, structural and functional characterization of conjugates, in which (i) various antitumour, antiparasitic compounds (e.g. daunomycin, methotrexate, GnRH analogue), (ii) imaging agents (e.g. radionuclides, fluorophores) or (iii) B- and/or T-cell epitope peptides from viral (e.g. Herpes simplex virus), bacterial (e.g. M. tuberculosis) and various disease (e.g. tumour, Alzheimer disease) related proteins are attached covalently to selected poly[Lys] branched polymeric polypeptides are discussed.

Original languageEnglish
Title of host publicationAmino Acids, Peptides and Proteins
Subtitle of host publicationVolume 43
EditorsHudecz Ferenc, Maxim Ryadnov
PublisherRoyal Society of Chemistry
Pages44-90
Number of pages47
ISBN (Electronic)9781788013673
DOIs
Publication statusPublished - Jan 1 2019

Publication series

NameAmino Acids, Peptides and Proteins
Volume43
ISSN (Print)1361-5904

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ASJC Scopus subject areas

  • Biochemistry

Cite this

Hudecz, F. (2019). Branched polymeric polypeptides with poly[Lys]. In H. Ferenc, & M. Ryadnov (Eds.), Amino Acids, Peptides and Proteins: Volume 43 (pp. 44-90). (Amino Acids, Peptides and Proteins; Vol. 43). Royal Society of Chemistry. https://doi.org/10.1039/9781788013857-00044