Brainstem projection to the hypothalamic ventromedial nucleus in the rat: A CCK-containing long ascending pathway

L. Záborszky, M. C. Beinfeld, M. Palkovits, L. Heimer

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60 Citations (Scopus)

Abstract

In order to identify the source and topography of cholecystokinin-containing fibers innervating the hypothalamic ventromedial nucleus (VMN), radioimmunoassay, immunocytochemistry, retrograde tracing of horseradish peroxidase and anterograde degeneration techniques were used. Cholecystokinin (CCK) disappeared almost totally from the VMN following a caudal diencephalic knife cut, which transected the medial fibers of the internal capsule, and the dorsolateral portion of the medial forebrain bundle at the level of the mammillary body. A number of cells in the ipsilateral dorsal parabrachial nucleus, furthermore, showed intense CCK-like immunoreactivity. The ascending CCK-containing fibers in the lateral part of the medial forebrain bundle reach the VMN from the lateral side. Neither the fibers of the stria terminalis, nor of the medial corticohypothalamic tract seem to carry any significant amount of CCK to the VMN.

Original languageEnglish
Pages (from-to)225-231
Number of pages7
JournalBrain research
Volume303
Issue number2
DOIs
Publication statusPublished - Jun 15 1984

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Keywords

  • CCK
  • HRP
  • anterograde degeneration
  • biochemistry
  • immunocytochemistry
  • parabrachial nucleus
  • ventromedial hypothalamic nucleus

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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