Brainstem nucleus incertus controls contextual memory formation

András Szőnyi, Katalin E. Sos, Rita Nyilas, Dániel Schlingloff, Andor Domonkos, Virág T. Takács, Balázs Pósfai, Panna Hegedüs, James B. Priestley, Andrew L. Gundlach, Attila I. Gulyás, V. Varga, Attila Losonczy, T. Freund, G. Nyíri

Research output: Contribution to journalArticle

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Abstract

Hippocampal pyramidal cells encode memory engrams, which guide adaptive behavior. Selection of engram-forming cells is regulated by somatostatin-positive dendrite-targeting interneurons, which inhibit pyramidal cells that are not required for memory formation. Here, we found that γ-aminobutyric acid (GABA)-releasing neurons of the mouse nucleus incertus (NI) selectively inhibit somatostatin-positive interneurons in the hippocampus, both monosynaptically and indirectly through the inhibition of their subcortical excitatory inputs. We demonstrated that NI GABAergic neurons receive monosynaptic inputs from brain areas processing important environmental information, and their hippocampal projections are strongly activated by salient environmental inputs in vivo. Optogenetic manipulations of NI GABAergic neurons can shift hippocampal network state and bidirectionally modify the strength of contextual fear memory formation. Our results indicate that brainstem NI GABAergic cells are essential for controlling contextual memories.

Original languageEnglish
JournalScience (New York, N.Y.)
Volume364
Issue number6442
DOIs
Publication statusPublished - May 24 2019

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Raphe Nuclei
GABAergic Neurons
Brain Stem
Pyramidal Cells
Interneurons
Somatostatin
Optogenetics
Aminobutyrates
Psychological Adaptation
Dendrites
Fear
Hippocampus
Brain

ASJC Scopus subject areas

  • General

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Szőnyi, A., Sos, K. E., Nyilas, R., Schlingloff, D., Domonkos, A., Takács, V. T., ... Nyíri, G. (2019). Brainstem nucleus incertus controls contextual memory formation. Science (New York, N.Y.), 364(6442). https://doi.org/10.1126/science.aaw0445

Brainstem nucleus incertus controls contextual memory formation. / Szőnyi, András; Sos, Katalin E.; Nyilas, Rita; Schlingloff, Dániel; Domonkos, Andor; Takács, Virág T.; Pósfai, Balázs; Hegedüs, Panna; Priestley, James B.; Gundlach, Andrew L.; Gulyás, Attila I.; Varga, V.; Losonczy, Attila; Freund, T.; Nyíri, G.

In: Science (New York, N.Y.), Vol. 364, No. 6442, 24.05.2019.

Research output: Contribution to journalArticle

Szőnyi, A, Sos, KE, Nyilas, R, Schlingloff, D, Domonkos, A, Takács, VT, Pósfai, B, Hegedüs, P, Priestley, JB, Gundlach, AL, Gulyás, AI, Varga, V, Losonczy, A, Freund, T & Nyíri, G 2019, 'Brainstem nucleus incertus controls contextual memory formation', Science (New York, N.Y.), vol. 364, no. 6442. https://doi.org/10.1126/science.aaw0445
Szőnyi A, Sos KE, Nyilas R, Schlingloff D, Domonkos A, Takács VT et al. Brainstem nucleus incertus controls contextual memory formation. Science (New York, N.Y.). 2019 May 24;364(6442). https://doi.org/10.1126/science.aaw0445
Szőnyi, András ; Sos, Katalin E. ; Nyilas, Rita ; Schlingloff, Dániel ; Domonkos, Andor ; Takács, Virág T. ; Pósfai, Balázs ; Hegedüs, Panna ; Priestley, James B. ; Gundlach, Andrew L. ; Gulyás, Attila I. ; Varga, V. ; Losonczy, Attila ; Freund, T. ; Nyíri, G. / Brainstem nucleus incertus controls contextual memory formation. In: Science (New York, N.Y.). 2019 ; Vol. 364, No. 6442.
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