Brain water accumulation after the central administration of vasopressin

T. Dóczi, P. Szerdahelyi, K. Gulya, J. Kiss

Research output: Contribution to journalArticle

70 Citations (Scopus)

Abstract

The intraventricular administration of vasopressin or DDAVP (desmopressin acetate) increased the brain water content from 78.2% to 79.2-79.5%. This was achieved without an accompanying water load. The applied water load alone did not increase the water content of the brain. There was no significant difference in the water content of the brain between animals treated with intraventricular vasopressin and intravenous water load and animals receiving only intraventricular vasopressin. The water content of the olfactory bulbs of the control animals was 3.8% higher than that of the hemispheres. While the water content of the hemispheres increased by 1.3%, that of the olfactory bulbs did so by 1.7% subsequent to the intraventricular administration of DDAVP. Measurement of the brain electrolyte content was not conclusive as to the mechanism of water permeability changes. The possible mechanism is discussed. Although no tissue or cerebrospinal fluid concentrations of vasopressin enabling comparison with clinical pathological conditions have been measured, it is suggested that increased secretion of vasopressin into the cerebrospinal fluid in conditions such as subarachnoid hemorrhage or intracranial hypertension of various origins might play a role in edema formation.

Original languageEnglish
Pages (from-to)402-407
Number of pages6
JournalNeurosurgery
Volume11
Issue number3
Publication statusPublished - 1982

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Vasopressins
Water
Brain
Deamino Arginine Vasopressin
Olfactory Bulb
Cerebrospinal Fluid
Intracranial Hypertension
Subarachnoid Hemorrhage
Electrolytes
Permeability
Edema

ASJC Scopus subject areas

  • Clinical Neurology
  • Surgery

Cite this

Brain water accumulation after the central administration of vasopressin. / Dóczi, T.; Szerdahelyi, P.; Gulya, K.; Kiss, J.

In: Neurosurgery, Vol. 11, No. 3, 1982, p. 402-407.

Research output: Contribution to journalArticle

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