Auswirkungen des hirntodes infolge akuter intrakranieller druckerhohung auf kontraktilitat und ischamietoleranz am isolierten hundeherz

Translated title of the contribution: Brain death-related effects on contractile function and ischemic tolerance in an isolated canine heart model

T. Hackert, G. Szabó, C. Sebening, C. F. Vahl, S. Hagl

Research output: Contribution to journalArticle

Abstract

Brain death related hemodynamic instability and cardiac dysfunction has been described in numerous experimental and clinical studies. The reasons for these changes taking place in potential organ donors remain unclear, especially concerning the role of brain death and ischemic preservation on cardiac function. In the present study the influence of these two aspects was investigated in a cross-circulated dog heart model. After either brain death or sham-operation and observation in situ for two hours, the hearts were perfused parabiotically either immediately or after hypothermic ischemic preservation (4°C for four hours). Despite a brain death associated hemodynamic deterioration in situ myocardial function was not impaired when assessed ex vivo. Furthermore, there was no evidence for a brain death related impairment of ischemic tolerance. Hemodynamic instability after brain death may therefore rather reflect altered loading conditions than primary cardiac dysfunction.

Original languageGerman
Pages (from-to)284-289
Number of pages6
JournalTransplantationsmedizin: Organ der Deutschen Transplantationsgesellschaft
Volume11
Issue number4
Publication statusPublished - 1999

Fingerprint

Brain Death
Canidae
Hemodynamics
Observation
Tissue Donors
Dogs

Keywords

  • Brain death
  • Cardiac dysfunction
  • Hemodynamic instability
  • Hyperdynamic response
  • Ischemic tolerance

ASJC Scopus subject areas

  • Immunology and Allergy
  • Transplantation

Cite this

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abstract = "Brain death related hemodynamic instability and cardiac dysfunction has been described in numerous experimental and clinical studies. The reasons for these changes taking place in potential organ donors remain unclear, especially concerning the role of brain death and ischemic preservation on cardiac function. In the present study the influence of these two aspects was investigated in a cross-circulated dog heart model. After either brain death or sham-operation and observation in situ for two hours, the hearts were perfused parabiotically either immediately or after hypothermic ischemic preservation (4°C for four hours). Despite a brain death associated hemodynamic deterioration in situ myocardial function was not impaired when assessed ex vivo. Furthermore, there was no evidence for a brain death related impairment of ischemic tolerance. Hemodynamic instability after brain death may therefore rather reflect altered loading conditions than primary cardiac dysfunction.",
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AU - Szabó, G.

AU - Sebening, C.

AU - Vahl, C. F.

AU - Hagl, S.

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AB - Brain death related hemodynamic instability and cardiac dysfunction has been described in numerous experimental and clinical studies. The reasons for these changes taking place in potential organ donors remain unclear, especially concerning the role of brain death and ischemic preservation on cardiac function. In the present study the influence of these two aspects was investigated in a cross-circulated dog heart model. After either brain death or sham-operation and observation in situ for two hours, the hearts were perfused parabiotically either immediately or after hypothermic ischemic preservation (4°C for four hours). Despite a brain death associated hemodynamic deterioration in situ myocardial function was not impaired when assessed ex vivo. Furthermore, there was no evidence for a brain death related impairment of ischemic tolerance. Hemodynamic instability after brain death may therefore rather reflect altered loading conditions than primary cardiac dysfunction.

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