Brain and CSF somatostatin concentrations in patients with psychiatric or neurological illness. An overview

L. Vécsei, E. Widerlov

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Somatostatin was originally isolated as a 14-amino-acid peptide from the ovine hypothalamus. The peptide has a widespread regional distribution within the central and peripheral nervous systems, as well as in peripheral organs. Preservation of the chemical structure over a wide range of vertebral species indicates important functional roles of the peptides. Recent results about the role of somatostatin and related peptides in different psychiatric (depression, schizophrenia, Alzheimer's disease) and neurological (Huntington's disease, multiple sclerosis, Parkinson's disease) diseases, and the effects on the hypothalamic-pituitary-adrenal axis are summarized. Also, the influence of some psychotropic drugs (haloperidol, carbamazepine) on somatostatin levels in cerebrospinal fluid is discussed.

Original languageEnglish
Pages (from-to)657-667
Number of pages11
JournalActa Psychiatrica Scandinavica
Volume78
Issue number6
Publication statusPublished - 1988

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Somatostatin
Psychiatry
Peptides
Brain
Psychotropic Drugs
Huntington Disease
Carbamazepine
Peripheral Nervous System
Haloperidol
Hypothalamus
Multiple Sclerosis
Parkinson Disease
Cerebrospinal Fluid
Sheep
Schizophrenia
Alzheimer Disease
Central Nervous System
Depression
Amino Acids

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Neuroscience(all)

Cite this

Brain and CSF somatostatin concentrations in patients with psychiatric or neurological illness. An overview. / Vécsei, L.; Widerlov, E.

In: Acta Psychiatrica Scandinavica, Vol. 78, No. 6, 1988, p. 657-667.

Research output: Contribution to journalArticle

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