Brain aging and disorders of the central nervous system: Kynurenines and drug metabolism

Nóra Török, Zsófia Majláth, Ferenc Fülöp, József Toldi, László Vécsei

Research output: Contribution to journalReview article

13 Citations (Scopus)

Abstract

Introduction: The kynurenine pathway includes several neuroactive compounds, including kynurenic acid, picolinic acid, 3-hydroxykynurenine and quinolinic acid. The enzymatic cascade of the kynurenine pathway is tightly connected with the immune system, and may provide a link between the immune system and neurotransmission. Main Areas Covered: Alterations in this cascade are associated with neurodegenerative, neurocognitive, autoimmune and psychiatric disorders, such as Parkinson's disease, Huntington's disease, Alzheimer's disease, multiple sclerosis, amyotrophic lateral sclerosis, migraine or schizophrenia. Highlights: This review highlights the alterations in this metabolic pathway in the physiological aging process and in different disorders. A survey is also presented of therapeutic possibilities of influencing this metabolic route, which can be achieved through the use of synthetic kynurenic acid analogues, enzyme inhibitors or even nanotechnology.

Original languageEnglish
Pages (from-to)412-429
Number of pages18
JournalCurrent Drug Metabolism
Volume17
Issue number5
DOIs
Publication statusPublished - Jun 1 2016

Keywords

  • Aging
  • Alzheimer's disease
  • Amyotrophic lateral sclerosis
  • Glutamate excitotoxicity
  • Huntington's disease
  • Kynurenine pathway
  • Migraine
  • Multiple sclerosis
  • Neurodegeneration
  • Neuroprotection
  • Parkinson's disease
  • Picolinic acid
  • Schizophrenia
  • Toxoplasma gondii

ASJC Scopus subject areas

  • Pharmacology
  • Clinical Biochemistry

Fingerprint Dive into the research topics of 'Brain aging and disorders of the central nervous system: Kynurenines and drug metabolism'. Together they form a unique fingerprint.

  • Cite this