An investigation was made of the state of bradykinin metabolism in the skin of normal subjects, in cases of artificially induced acute inflammations and in cases of chronic untreated dermatoses. In the skin of normal subjects no bradykinin substrate nor bradykininogenase could be detected. The inflamed human skin contained considerable quantities of bradykininogen and active kininogenase. The bradykininogen in both acute and chronic inflammatory states had a mol wt of 50,000 - 60,000. The inflamed skin contained only a very small amount of the kininases found in normal human skin. Homogenates both of healthy skin and inflamed skin were shown to contain 3 kininases of different mol. wt. separated by filtration on Sephadex gel.
|Number of pages||8|
|Publication status||Published - Jan 1 1974|
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