Bradykinin-induced venodilation is not different in blacks

Zoltan Vajo, Mark McDonald, Bruce Takahashi, Haider Zafar, Komandor Srivathsan, William Dachman

Research output: Contribution to journalArticle

Abstract

Aims. The aim of this study was to determine whether young, normotensive blacks who have been recently demonstrated to have a venodilator response to isoprenaline decreased compared with whites, also have an decreased vasodilatory response to bradykinin. Methods. Eleven black and 11 white subjects were studied. Full dose-response curves to bradykinin (dosing range 0.5-500 ng min-1) were generated in hand veins preconstricted with phenylephrine (dosing range 20-6800 ng min-1). Results. The groups had a similar maximal response to bradykinin (57.6 ± 32.2% vs 67.8 ± 49.3%, P = NS 95% confidence interval for the difference (CI): -47.3, 26.8). Also, the log of the dose that produced half maximal response to bradykinin was similar for the two groups (0.89 ± 0.58 vs 0.78 ± 0.61 ng min-1, P = NS, 95% CI: -0.42, 0.64). There was no difference between the two groups in the log dose of phenylephrine necessary to produce 80% constriction of the hand vein. Conclusion. Diminished vasodilatory response to endothelium-derived relaxing factor (EDRF) does not seem to be associated with the increased prevalence of hypertension in blacks.

Original languageEnglish
Pages (from-to)285-288
Number of pages4
JournalBritish Journal of Clinical Pharmacology
Volume44
Issue number3
Publication statusPublished - 1997

Fingerprint

Bradykinin
Phenylephrine
Veins
Hand
Endothelium-Dependent Relaxing Factors
Isoproterenol
Constriction
Confidence Intervals
Hypertension

Keywords

  • Blacks
  • Bradykinin
  • Vasodilation
  • Vein EDRF

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Vajo, Z., McDonald, M., Takahashi, B., Zafar, H., Srivathsan, K., & Dachman, W. (1997). Bradykinin-induced venodilation is not different in blacks. British Journal of Clinical Pharmacology, 44(3), 285-288.

Bradykinin-induced venodilation is not different in blacks. / Vajo, Zoltan; McDonald, Mark; Takahashi, Bruce; Zafar, Haider; Srivathsan, Komandor; Dachman, William.

In: British Journal of Clinical Pharmacology, Vol. 44, No. 3, 1997, p. 285-288.

Research output: Contribution to journalArticle

Vajo, Z, McDonald, M, Takahashi, B, Zafar, H, Srivathsan, K & Dachman, W 1997, 'Bradykinin-induced venodilation is not different in blacks', British Journal of Clinical Pharmacology, vol. 44, no. 3, pp. 285-288.
Vajo Z, McDonald M, Takahashi B, Zafar H, Srivathsan K, Dachman W. Bradykinin-induced venodilation is not different in blacks. British Journal of Clinical Pharmacology. 1997;44(3):285-288.
Vajo, Zoltan ; McDonald, Mark ; Takahashi, Bruce ; Zafar, Haider ; Srivathsan, Komandor ; Dachman, William. / Bradykinin-induced venodilation is not different in blacks. In: British Journal of Clinical Pharmacology. 1997 ; Vol. 44, No. 3. pp. 285-288.
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