Brachytherapy of vestibular schwannomas

Report of three cases

Árpád Viola, T. Major, L. Mangel, G. Nemeth, J. Julow

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Objective: Gamma knife and multileaf collimator LINAC have recently gained notority in the treatment of vestibular schwannomas. Without the use of gamma knife or LINAC, we have successfully pursued the 125-iodine interstitial irradiation of three vestibular schwannomas. Case Report: Up to March 2004, there was a 57 and 45 month follow-up period in two cases. One patient died of heart insufficiency 15 months after the brachytherapy. At the end of the follow-up period audiometric examinations revealed slight improvements of hearing in patients 1 and 2. In patient 1, the tumor volume measured was 4.06 mL on the control CT indicating a 40% shrinkage in comparison to the 6.74 mL target volume at the brachytherapy. In patient 2, the tumor volume measured on the control MRI was 6.64 mL, indicating a 42% shrinkage of the 11.45 mL target volume at the time of brachytherapy. Eleven months after the brachytherapy in patient 3 we found 10% tumor shrinkage, a post-irradiation cyst developed inside the tumor and reached up to 3 5 % of the tumor volume. Intervention: In the treatment of three vestibular schwannomas we have used CT and image-fusion guided 125-iodine stereotactic brachytherapy. Conclusion: Due to financial considerations, gamma knife and LINAC are not available for many countries and neurosurgical institutes. In the absence of the above-mentioned radiosurgical methods, we have shown brachytherapy as a new alternative and solution in the treatment of the three patients studied with vestibular schwannoma.

Original languageEnglish
Pages (from-to)382-385
Number of pages4
JournalMinimally Invasive Neurosurgery
Volume47
Issue number6
DOIs
Publication statusPublished - Dec 2004

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Acoustic Neuroma
Brachytherapy
Tumor Burden
Iodine
Hearing
Cysts
Neoplasms
Therapeutics

Keywords

  • Brachytherapy
  • Image fusion
  • Vestibular schwannoma

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Brachytherapy of vestibular schwannomas : Report of three cases. / Viola, Árpád; Major, T.; Mangel, L.; Nemeth, G.; Julow, J.

In: Minimally Invasive Neurosurgery, Vol. 47, No. 6, 12.2004, p. 382-385.

Research output: Contribution to journalArticle

Viola, Árpád ; Major, T. ; Mangel, L. ; Nemeth, G. ; Julow, J. / Brachytherapy of vestibular schwannomas : Report of three cases. In: Minimally Invasive Neurosurgery. 2004 ; Vol. 47, No. 6. pp. 382-385.
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