Bourneville-Pringle Disease for Kidney Transplantation: A Single-Center Experience

G. Dallos, R. Chmel, F. Alföldy, S. Török, G. Telkes, C. Diczházi, F. Perner, J. Járay, R. Langer

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The Bourneville-Pringle disease is an autosomal-dominant disease affecting the kidneys in about 60%, causing end-stage renal disease in about 10% of the cases. Among more than 2800 renal transplant recipients during the last 33 years, we had two patients with this original disease. A third patient who underwent bilateral nephrectomy is currently awaiting a graft. The first patient was diagnosed at the age of 20 years after a few episodes of retroperitoneal bleeding. At the age of 26 years her left kidney was removed after a rupture; it measured 7500 g, and the histology described angiomyolipomatosis. A year later she underwent a cadaveric kidney transplantation. Subsequently her right kidney was removed due to bleeding. She is currently 5 years posttransplant with stable kidney function and good health. Our second patient was nephrectomized at the age of 35 years and 38 years because of angiomyolipomatosis. She underwent a cadaveric kidney transplantation 7 years later. After 5 years of excellent kidney function and a year after her arteriovenous fistula was ligated her upperarm had to be amputated because of uncontrollable bleeding. After another 6 months, she displayed rapid progression of a jejunal tumor and during operation received 54 U of blood transfusion but died at the age of 49 years with a well-functioning graft. Our third patient consecutively underwent two nephrectomies because of angiomyolipomatosis of her kidneys at the ages of 25 and 28 years. She has two children with the same disease. In addition she carries Leyden mutation, which has caused deep venous thromboses and pulmonary emboli. She is currently on our waiting list for kidney transplantation. The Bourneville-Pringle disease is a rare indication for kidney transplantation; the prognosis of the patient is dependent on the original disease.

Original languageEnglish
Pages (from-to)2823-2824
Number of pages2
JournalTransplantation Proceedings
Volume38
Issue number9
DOIs
Publication statusPublished - Nov 2006

Fingerprint

Tuberous Sclerosis
Kidney Transplantation
Kidney
Hemorrhage
Nephrectomy
Transplants
Waiting Lists
Arteriovenous Fistula
Kidney Diseases
Embolism
Venous Thrombosis
Blood Transfusion
Chronic Kidney Failure
Rupture
Histology
Lung
Mutation
Health
Neoplasms

ASJC Scopus subject areas

  • Surgery
  • Transplantation

Cite this

Bourneville-Pringle Disease for Kidney Transplantation : A Single-Center Experience. / Dallos, G.; Chmel, R.; Alföldy, F.; Török, S.; Telkes, G.; Diczházi, C.; Perner, F.; Járay, J.; Langer, R.

In: Transplantation Proceedings, Vol. 38, No. 9, 11.2006, p. 2823-2824.

Research output: Contribution to journalArticle

Dallos, G. ; Chmel, R. ; Alföldy, F. ; Török, S. ; Telkes, G. ; Diczházi, C. ; Perner, F. ; Járay, J. ; Langer, R. / Bourneville-Pringle Disease for Kidney Transplantation : A Single-Center Experience. In: Transplantation Proceedings. 2006 ; Vol. 38, No. 9. pp. 2823-2824.
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