Botulinum toxin-induced ADP-ribosylation and inhibition of exocytosis are unrelated events

V. Adam-Vizi, S. Rosener, K. Aktories, D. E. Knight

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

The hypothesis that inhibition of secretion by botulinum neurotoxin type D occurs by an intracellular process involving ADP-ribosylation has been directly tested by measuring both the extent of inhibition of secretion and of ADP-ribosylation in the same cells. Although the inhibitory effect of unpurified toxin closely parallels intracellular ribosylation, the two events are clearly unrelated, as using purified D and C3 toxins together with their antibodies, each of these events can be either stimulated or inhibited independently of each other.

Original languageEnglish
Pages (from-to)277-280
Number of pages4
JournalFEBS letters
Volume238
Issue number2
DOIs
Publication statusPublished - Oct 10 1988

Keywords

  • (Adrenal medulla)
  • ADP-ribosylation
  • Botulinum toxin
  • Catecholamine
  • Exocytosis

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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