Both nitric oxide and endothelin-1 influence cerebral blood flow velocity at rest and after hyper- and hypocapnic stimuli in hypertensive and healthy adolescents

E. Katona, Georgios Settakis, Z. Varga, Mária Juhász, G. Paragh, D. Bereczki, B. Fülesdi, D. Páll

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Background and Purpose: Nitric oxide (NO)/endothelin imbalance may play a role in the regulation of cerebral blood flow. The aim of the present study was to assess whether these endothelial factors influence middle cerebral artery blood flow velocities (MCAV) and cerebrovascular reactivity (CVR) in healthy and hypertensive adolescents. Subjects and Methods: 106 adolescents (61 hypertensive and 45 normotensive) underwent transcranial Doppler measurements of the middle cerebral artery at rest and after 30 s of breath-holding (BH) and 60 s of hyperventilation (HV). Additionally, NO and endothelin-1 (ET-1) concentrations of the serum were assessed. The correlation between NO and ET-1 levels as well as MCAV and CVR values was analyzed. Results: Resting MCAVs were higher among hypertensive teenagers (76.5 ± 24 vs. 62.8 ± 15.6 cm/s, respectively, p <0.001). CVR values did not differ between hypertensive and healthy adolescents after the BH and HV procedure. A significant negative correlation was found between absolute MCAV values and NO concentrations. ET-1 was positively related to MCAV. Conclusions: Cerebral blood flow velocities, but not CVR values, are associated with serum NO and ET-1 concentrations in adolescents.

Original languageEnglish
Pages (from-to)152-158
Number of pages7
JournalKidney and Blood Pressure Research
Volume29
Issue number3
DOIs
Publication statusPublished - Oct 2006

Fingerprint

Cerebrovascular Circulation
Blood Flow Velocity
Endothelin-1
Middle Cerebral Artery
Nitric Oxide
Breath Holding
Hyperventilation
Endothelins
Serum

Keywords

  • Adolescent hypertension
  • Cerebral blood flow
  • Endothelin
  • Nitric oxide

ASJC Scopus subject areas

  • Physiology
  • Nephrology
  • Cardiology and Cardiovascular Medicine

Cite this

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title = "Both nitric oxide and endothelin-1 influence cerebral blood flow velocity at rest and after hyper- and hypocapnic stimuli in hypertensive and healthy adolescents",
abstract = "Background and Purpose: Nitric oxide (NO)/endothelin imbalance may play a role in the regulation of cerebral blood flow. The aim of the present study was to assess whether these endothelial factors influence middle cerebral artery blood flow velocities (MCAV) and cerebrovascular reactivity (CVR) in healthy and hypertensive adolescents. Subjects and Methods: 106 adolescents (61 hypertensive and 45 normotensive) underwent transcranial Doppler measurements of the middle cerebral artery at rest and after 30 s of breath-holding (BH) and 60 s of hyperventilation (HV). Additionally, NO and endothelin-1 (ET-1) concentrations of the serum were assessed. The correlation between NO and ET-1 levels as well as MCAV and CVR values was analyzed. Results: Resting MCAVs were higher among hypertensive teenagers (76.5 ± 24 vs. 62.8 ± 15.6 cm/s, respectively, p <0.001). CVR values did not differ between hypertensive and healthy adolescents after the BH and HV procedure. A significant negative correlation was found between absolute MCAV values and NO concentrations. ET-1 was positively related to MCAV. Conclusions: Cerebral blood flow velocities, but not CVR values, are associated with serum NO and ET-1 concentrations in adolescents.",
keywords = "Adolescent hypertension, Cerebral blood flow, Endothelin, Nitric oxide",
author = "E. Katona and Georgios Settakis and Z. Varga and M{\'a}ria Juh{\'a}sz and G. Paragh and D. Bereczki and B. F{\"u}lesdi and D. P{\'a}ll",
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T1 - Both nitric oxide and endothelin-1 influence cerebral blood flow velocity at rest and after hyper- and hypocapnic stimuli in hypertensive and healthy adolescents

AU - Katona, E.

AU - Settakis, Georgios

AU - Varga, Z.

AU - Juhász, Mária

AU - Paragh, G.

AU - Bereczki, D.

AU - Fülesdi, B.

AU - Páll, D.

PY - 2006/10

Y1 - 2006/10

N2 - Background and Purpose: Nitric oxide (NO)/endothelin imbalance may play a role in the regulation of cerebral blood flow. The aim of the present study was to assess whether these endothelial factors influence middle cerebral artery blood flow velocities (MCAV) and cerebrovascular reactivity (CVR) in healthy and hypertensive adolescents. Subjects and Methods: 106 adolescents (61 hypertensive and 45 normotensive) underwent transcranial Doppler measurements of the middle cerebral artery at rest and after 30 s of breath-holding (BH) and 60 s of hyperventilation (HV). Additionally, NO and endothelin-1 (ET-1) concentrations of the serum were assessed. The correlation between NO and ET-1 levels as well as MCAV and CVR values was analyzed. Results: Resting MCAVs were higher among hypertensive teenagers (76.5 ± 24 vs. 62.8 ± 15.6 cm/s, respectively, p <0.001). CVR values did not differ between hypertensive and healthy adolescents after the BH and HV procedure. A significant negative correlation was found between absolute MCAV values and NO concentrations. ET-1 was positively related to MCAV. Conclusions: Cerebral blood flow velocities, but not CVR values, are associated with serum NO and ET-1 concentrations in adolescents.

AB - Background and Purpose: Nitric oxide (NO)/endothelin imbalance may play a role in the regulation of cerebral blood flow. The aim of the present study was to assess whether these endothelial factors influence middle cerebral artery blood flow velocities (MCAV) and cerebrovascular reactivity (CVR) in healthy and hypertensive adolescents. Subjects and Methods: 106 adolescents (61 hypertensive and 45 normotensive) underwent transcranial Doppler measurements of the middle cerebral artery at rest and after 30 s of breath-holding (BH) and 60 s of hyperventilation (HV). Additionally, NO and endothelin-1 (ET-1) concentrations of the serum were assessed. The correlation between NO and ET-1 levels as well as MCAV and CVR values was analyzed. Results: Resting MCAVs were higher among hypertensive teenagers (76.5 ± 24 vs. 62.8 ± 15.6 cm/s, respectively, p <0.001). CVR values did not differ between hypertensive and healthy adolescents after the BH and HV procedure. A significant negative correlation was found between absolute MCAV values and NO concentrations. ET-1 was positively related to MCAV. Conclusions: Cerebral blood flow velocities, but not CVR values, are associated with serum NO and ET-1 concentrations in adolescents.

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