Bone mineral density and bone acquisition in children and young adults with cystic fibrosis

a follow-up study.

Rita Ujhelyi, András Treszl, B. Vásárhelyi, Klára Holics, Miklós Tóth, A. Arató, T. Tulassay, Z. Tulassay, M. Szathmári

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

OBJECTIVE: To investigate bone mineral density and bone homeostasis in cystic fibrosis (CF) and to assess changes in a 2-year period. METHODS: Thirty-eight patients with clinically stable CF (11 children, 16 adolescents, 11 young adults) were enrolled. No patient was treated with corticosteroids before or during the study. Weight and height Z scores and bone mineral density (BMD) Z-score at the femoral neck and the lumbar spine were recorded at the beginning of the study and after 2 years. Osteocalcin and cross-link excretion, both measurements of bone turnover were also measured. Correlations between BMD, bone turnover parameters, disease severity, pubertal stage, and nutritional state were calculated. The maternal BMD was also determined and related to that of the child. RESULTS: Height and weight Z scores were normal in children and below normal in adolescents. Puberty was delayed in most patients. Bone age was lower than chronological age in adolescents. Lumbar spine and femoral neck BMD Z scores were below normal in each age group. Disease severity determined by Schwachman score correlated with lumbar BMD (r = 0.45, P <0.02). BMD Z scores did not change during 2 year follow-up. Maternal and patient lumbar and femoral BMD correlated significantly (r = 0.51, P <0.01, and r = 0.54, P <0.01, respectively). CONCLUSIONS: Bone deficit is present in patients with CF who have never received steroid treatment. Delay of puberty, chronic inflammation, or genetic susceptibility might be responsible for this phenomenon which was found in patients who had never received steroids and who were in relatively good clinical state.

Original languageEnglish
Pages (from-to)401-406
Number of pages6
JournalJournal of Pediatric Gastroenterology and Nutrition
Volume38
Issue number4
Publication statusPublished - Apr 2004

Fingerprint

cystic fibrosis
bone density
young adults
Cystic Fibrosis
Bone Density
Young Adult
bones
Bone and Bones
thighs
lumbar spine
Bone Remodeling
Femur Neck
puberty
disease severity
steroids
Spine
Steroids
Mothers
Delayed Puberty
Weights and Measures

ASJC Scopus subject areas

  • Gastroenterology
  • Histology
  • Medicine (miscellaneous)
  • Food Science
  • Pediatrics, Perinatology, and Child Health

Cite this

Bone mineral density and bone acquisition in children and young adults with cystic fibrosis : a follow-up study. / Ujhelyi, Rita; Treszl, András; Vásárhelyi, B.; Holics, Klára; Tóth, Miklós; Arató, A.; Tulassay, T.; Tulassay, Z.; Szathmári, M.

In: Journal of Pediatric Gastroenterology and Nutrition, Vol. 38, No. 4, 04.2004, p. 401-406.

Research output: Contribution to journalArticle

@article{85a20537f538417db114f097e1340629,
title = "Bone mineral density and bone acquisition in children and young adults with cystic fibrosis: a follow-up study.",
abstract = "OBJECTIVE: To investigate bone mineral density and bone homeostasis in cystic fibrosis (CF) and to assess changes in a 2-year period. METHODS: Thirty-eight patients with clinically stable CF (11 children, 16 adolescents, 11 young adults) were enrolled. No patient was treated with corticosteroids before or during the study. Weight and height Z scores and bone mineral density (BMD) Z-score at the femoral neck and the lumbar spine were recorded at the beginning of the study and after 2 years. Osteocalcin and cross-link excretion, both measurements of bone turnover were also measured. Correlations between BMD, bone turnover parameters, disease severity, pubertal stage, and nutritional state were calculated. The maternal BMD was also determined and related to that of the child. RESULTS: Height and weight Z scores were normal in children and below normal in adolescents. Puberty was delayed in most patients. Bone age was lower than chronological age in adolescents. Lumbar spine and femoral neck BMD Z scores were below normal in each age group. Disease severity determined by Schwachman score correlated with lumbar BMD (r = 0.45, P <0.02). BMD Z scores did not change during 2 year follow-up. Maternal and patient lumbar and femoral BMD correlated significantly (r = 0.51, P <0.01, and r = 0.54, P <0.01, respectively). CONCLUSIONS: Bone deficit is present in patients with CF who have never received steroid treatment. Delay of puberty, chronic inflammation, or genetic susceptibility might be responsible for this phenomenon which was found in patients who had never received steroids and who were in relatively good clinical state.",
author = "Rita Ujhelyi and Andr{\'a}s Treszl and B. V{\'a}s{\'a}rhelyi and Kl{\'a}ra Holics and Mikl{\'o}s T{\'o}th and A. Arat{\'o} and T. Tulassay and Z. Tulassay and M. Szathm{\'a}ri",
year = "2004",
month = "4",
language = "English",
volume = "38",
pages = "401--406",
journal = "Journal of Pediatric Gastroenterology and Nutrition",
issn = "0277-2116",
publisher = "Lippincott Williams and Wilkins",
number = "4",

}

TY - JOUR

T1 - Bone mineral density and bone acquisition in children and young adults with cystic fibrosis

T2 - a follow-up study.

AU - Ujhelyi, Rita

AU - Treszl, András

AU - Vásárhelyi, B.

AU - Holics, Klára

AU - Tóth, Miklós

AU - Arató, A.

AU - Tulassay, T.

AU - Tulassay, Z.

AU - Szathmári, M.

PY - 2004/4

Y1 - 2004/4

N2 - OBJECTIVE: To investigate bone mineral density and bone homeostasis in cystic fibrosis (CF) and to assess changes in a 2-year period. METHODS: Thirty-eight patients with clinically stable CF (11 children, 16 adolescents, 11 young adults) were enrolled. No patient was treated with corticosteroids before or during the study. Weight and height Z scores and bone mineral density (BMD) Z-score at the femoral neck and the lumbar spine were recorded at the beginning of the study and after 2 years. Osteocalcin and cross-link excretion, both measurements of bone turnover were also measured. Correlations between BMD, bone turnover parameters, disease severity, pubertal stage, and nutritional state were calculated. The maternal BMD was also determined and related to that of the child. RESULTS: Height and weight Z scores were normal in children and below normal in adolescents. Puberty was delayed in most patients. Bone age was lower than chronological age in adolescents. Lumbar spine and femoral neck BMD Z scores were below normal in each age group. Disease severity determined by Schwachman score correlated with lumbar BMD (r = 0.45, P <0.02). BMD Z scores did not change during 2 year follow-up. Maternal and patient lumbar and femoral BMD correlated significantly (r = 0.51, P <0.01, and r = 0.54, P <0.01, respectively). CONCLUSIONS: Bone deficit is present in patients with CF who have never received steroid treatment. Delay of puberty, chronic inflammation, or genetic susceptibility might be responsible for this phenomenon which was found in patients who had never received steroids and who were in relatively good clinical state.

AB - OBJECTIVE: To investigate bone mineral density and bone homeostasis in cystic fibrosis (CF) and to assess changes in a 2-year period. METHODS: Thirty-eight patients with clinically stable CF (11 children, 16 adolescents, 11 young adults) were enrolled. No patient was treated with corticosteroids before or during the study. Weight and height Z scores and bone mineral density (BMD) Z-score at the femoral neck and the lumbar spine were recorded at the beginning of the study and after 2 years. Osteocalcin and cross-link excretion, both measurements of bone turnover were also measured. Correlations between BMD, bone turnover parameters, disease severity, pubertal stage, and nutritional state were calculated. The maternal BMD was also determined and related to that of the child. RESULTS: Height and weight Z scores were normal in children and below normal in adolescents. Puberty was delayed in most patients. Bone age was lower than chronological age in adolescents. Lumbar spine and femoral neck BMD Z scores were below normal in each age group. Disease severity determined by Schwachman score correlated with lumbar BMD (r = 0.45, P <0.02). BMD Z scores did not change during 2 year follow-up. Maternal and patient lumbar and femoral BMD correlated significantly (r = 0.51, P <0.01, and r = 0.54, P <0.01, respectively). CONCLUSIONS: Bone deficit is present in patients with CF who have never received steroid treatment. Delay of puberty, chronic inflammation, or genetic susceptibility might be responsible for this phenomenon which was found in patients who had never received steroids and who were in relatively good clinical state.

UR - http://www.scopus.com/inward/record.url?scp=7444270004&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=7444270004&partnerID=8YFLogxK

M3 - Article

VL - 38

SP - 401

EP - 406

JO - Journal of Pediatric Gastroenterology and Nutrition

JF - Journal of Pediatric Gastroenterology and Nutrition

SN - 0277-2116

IS - 4

ER -