Bone metabolism and arterial stiffness after renal transplantation

Orsolya Cseprekál, Eva Kis, Arianna A. Dégi, Andrea Kerti, Attila J. Szabó, G. Reusz

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Background/Aims: To assess the relationship between bone and vascular disease and its changes over time after renal transplantation. Metabolic bone disease (MBD) is common in chronic kidney disease (CKD) and is associated with cardiovascular (CV) disease. Following transplantation (Tx), improvement in CV disease has been reported; however, data regarding changes in bone disease remain controversial. Methods: Bone turnover and arterial stiffness (pulse wave velocity (PWV)) were assessed in 47 Tx patients (38 (3-191) months after Tx). Results: Bone alkaline phosphatase (BALP), osteocalcin (OC) and beta-crosslaps were significantly higher in Tx patients, and decreased significantly after one year. There was a negative correlation between BALP, OC and steroid administered (r=-0.35;r=-0.36 respectively). PWV increased in the Tx group (1.15 SD). In patients with a follow up of

Original languageEnglish
Pages (from-to)507-515
Number of pages9
JournalKidney and Blood Pressure Research
Volume39
Issue number6
DOIs
Publication statusPublished - Jan 13 2014

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Vascular Stiffness
Kidney Transplantation
Pulse Wave Analysis
glutamyl-lysyl-alanyl-histidyl-aspartyl-glycyl-glycyl-arginine
Bone Diseases
Osteocalcin
Bone and Bones
Alkaline Phosphatase
Cardiovascular Diseases
Bone Remodeling
Metabolic Bone Diseases
Chronic Renal Insufficiency
Vascular Diseases
Transplantation
Steroids

Keywords

  • Arterial stiffness
  • Bone turnover
  • Chronic kidney disease
  • Metabolic bone disease
  • Transplantation

ASJC Scopus subject areas

  • Nephrology
  • Cardiology and Cardiovascular Medicine
  • Medicine(all)

Cite this

Bone metabolism and arterial stiffness after renal transplantation. / Cseprekál, Orsolya; Kis, Eva; Dégi, Arianna A.; Kerti, Andrea; Szabó, Attila J.; Reusz, G.

In: Kidney and Blood Pressure Research, Vol. 39, No. 6, 13.01.2014, p. 507-515.

Research output: Contribution to journalArticle

Cseprekál, O, Kis, E, Dégi, AA, Kerti, A, Szabó, AJ & Reusz, G 2014, 'Bone metabolism and arterial stiffness after renal transplantation', Kidney and Blood Pressure Research, vol. 39, no. 6, pp. 507-515. https://doi.org/10.1159/000368461
Cseprekál, Orsolya ; Kis, Eva ; Dégi, Arianna A. ; Kerti, Andrea ; Szabó, Attila J. ; Reusz, G. / Bone metabolism and arterial stiffness after renal transplantation. In: Kidney and Blood Pressure Research. 2014 ; Vol. 39, No. 6. pp. 507-515.
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