Bone marrow transplantation in non-malignant disorders

G. Kriván, L. Timár, V. Goda, M. Réti, P. Reményi, T. Masszi

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Abstract

From January 1992 to December 1997, 21 consecutive patients (14 SAA, 3 SCID, 1 Fanconi anemia, 1 Diamond-Blackfan anemia, 1 mucolipidosis and 1 mucopolysaccharidosis type I.) were transplanted (16 HLA-id. family, 2 MUD and 3 haploidentical family donors) in a single center. The median follow up period is 41 months (range 7-76). The probability of 3.5 year overall disease free survival is 14/21 (67%), the transplant related mortality is 4/21 (19%). All the SCID patients are alive and disease free. 3 SAA patients had signs of fungal infection prior to transplant. They died in spite of intensive antifungal treatment resulting reduced DFS for SAA to 71%. Two patients with lysosomal storage disorders (mucolipidosis and MPS I.) rejected the haploidentical T-cell depleted graft 1 and 11 months after transplant, respectively. In 2 cases non-engraftment occured, both patients were retransplanted succesfully.

Original languageEnglish
Pages (from-to)S80-S83
JournalBone Marrow Transplantation
Volume22
Issue numberSUPPL. 4
Publication statusPublished - Dec 1 1998

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ASJC Scopus subject areas

  • Hematology
  • Transplantation

Cite this

Kriván, G., Timár, L., Goda, V., Réti, M., Reményi, P., & Masszi, T. (1998). Bone marrow transplantation in non-malignant disorders. Bone Marrow Transplantation, 22(SUPPL. 4), S80-S83.