Bone health in breast cancer patients: A comprehensive statement by CECOG/SAKK Intergroup

Tamara Rordorf, Azza Adel Hassan, Hamdy Azim, Eniu Alexandru, Ozlem Er, Erhan Gokmen, Zeynep Güral, Jozef Mardiak, Velko Minchev, Florentia Peintinger, Miklos Szendroi, Itzok Takac, Petra Tesarova, Daniel Vorobiof, Damir Vrbanec, Ramazan Yildiz, Serap Yücel, Jamal Zekri, Basak Oyan

Research output: Contribution to journalReview article

11 Citations (Scopus)


Bone is the most common site of distant metastases in breast cancer that can cause severe and debilitating skeletal related events (SRE) including hypercalcemia of malignancy, pathologic fracture, spinal cord compression and the need for palliative radiation therapy or surgery to the bone. SRE are associated with substantial pain and morbidity leading to frequent hospitalization, impaired quality of life and poor prognosis. The past 25 years of research on the pathophysiology of bone metastases led to the development of highly effective treatment options to delay or prevent osseous metastases and SRE. Management of bone metastases has become an integral part of cancer treatment requiring expertise of multidisciplinary teams of medical and radiation oncologists, surgeons and radiologists in order to find an optimal treatment for each individual patient.A group of international breast cancer experts attended a Skeletal Care Academy Meeting in November 2012 in Istanbul and discussed current preventive measures and treatment options of SRE, which are summarized in this evidence-based consensus for qualified decision- making in clinical practice.

Original languageEnglish
Pages (from-to)511-525
Number of pages15
Issue number5
Publication statusPublished - Oct 1 2014


  • Bisphosphonates
  • Bone metastases
  • Denosumab
  • Metastatic breast cancer
  • Radiotherapy
  • Skeletal-related events

ASJC Scopus subject areas

  • Surgery

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    Rordorf, T., Hassan, A. A., Azim, H., Alexandru, E., Er, O., Gokmen, E., Güral, Z., Mardiak, J., Minchev, V., Peintinger, F., Szendroi, M., Takac, I., Tesarova, P., Vorobiof, D., Vrbanec, D., Yildiz, R., Yücel, S., Zekri, J., & Oyan, B. (2014). Bone health in breast cancer patients: A comprehensive statement by CECOG/SAKK Intergroup. Breast, 23(5), 511-525.