Body weight changes after neurochemical manipulations of lateral amygdala: Noradrenergic and dopaminergic mechanisms

L. Lénárd, Zoltán Hahn, Zoltán Karádi

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

The feeding behavior of rats was studied after neurochemical lesions of lateral amygdalar terminal fields of mesolimbic dopaminergic (DA) and coerular noradrenergic (NA) systems. 6-Hydroxydopamine (6-OHDA) with or without desmethylimipramine (DMI) premedication was bilaterally injected into the lateral amygdala or periamygdaloid-piriform area. Lateral amygdalar injections of 6-OHDA resulted in hyperdipsia, hyperphagia and body weight increase with a relative decrease in amygdalar NA concentration, while 6-OHDA plus DMI treatments were followed by weight decrease and a mild decrease in DA level. When the cannulas were placed into the periamygdaloid-piriform cortex nothing but body weight increase developed. The importance of the actual balance of the two amygdalar catecholaminergic (CA) systems in feeding is discussed.

Original languageEnglish
Pages (from-to)95-101
Number of pages7
JournalBrain Research
Volume249
Issue number1
DOIs
Publication statusPublished - Oct 7 1982

Fingerprint

Body Weight Changes
Oxidopamine
Amygdala
Desipramine
Body Weight
Hyperphagia
Premedication
Feeding Behavior
Weights and Measures
Injections
Piriform Cortex
Periamygdaloid Cortex
Therapeutics

Keywords

  • 6-hydroxydopamine
  • balance of catecholamines in the amygdala
  • body weight regulation
  • coerular noradrenergic pathways
  • desmethylimipramine
  • food and water intake
  • lateral amygdala
  • mesolimbic dopaminergic system
  • periamygdaloid
  • piriform cortex

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Body weight changes after neurochemical manipulations of lateral amygdala : Noradrenergic and dopaminergic mechanisms. / Lénárd, L.; Hahn, Zoltán; Karádi, Zoltán.

In: Brain Research, Vol. 249, No. 1, 07.10.1982, p. 95-101.

Research output: Contribution to journalArticle

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