BMI is an important driver of β-cell loss in type 1 diabetes upon diagnosis in 10 to 18-year-old children

A. Lauria, A. Barker, N. Schloot, N. Hosszúfalusi, J. Ludvigsson, C. Mathieu, D. Mauricio, M. Nordwall, B. Van Der Schueren, T. Mandrup-Poulsen, W. A. Scherbaum, I. Weets, F. K. Gorus, N. Wareham, R. D. Leslie, P. Pozzilli

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Objective: Body weight-related insulin resistance probably plays a role in progression to type 1 diabetes, but has an uncertain impact following diagnosis. In this study, we investigated whether BMI measured at diagnosis was an independent predictor of C-peptide decline 1-year post-diagnosis. Design: Multicentre longitudinal study carried out at diagnosis and up to 1-year follow-up. Methods: Data on C-peptide were collected from seven diabetes centres in Europe. Patients were grouped according to age at diagnosis (5 years 10 years 18 years, n=410). Linear regression was used to investigate whether BMI was an independent predictor of change in fasting C-peptide over 1 year. Models were additionally adjusted for baseline insulin dose and HbA1c. Results: In individuals diagnosed between 0 and 5 years, 5 and 10 years and those diagnosed >18 years, we found no association between BMI and C-peptide decline. In patients aged 10-18 years, higher BMI at baseline was associated with a greater decline in fasting C-peptide over 1 year with a decrease (β 95% CI; P value) of 0.025 (0.010, 0.041) nM/kg per m2 higher baseline BMI (P=0.001). This association remained significant after adjusting for gender and differences in HbA1c and insulin dose (β=0.026, 95% CI=0.0097, 0.042; P=0.002). Conclusions: These observations indicate that increased body weight and increased insulin demand are associated with more rapid disease progression after diagnosis of type 1 diabetes in an age group 10-18 years. This should be considered in studies of β-cell function in type 1 diabetes.

Original languageEnglish
Pages (from-to)107-113
Number of pages7
JournalEuropean Journal of Endocrinology
Volume172
Issue number2
DOIs
Publication statusPublished - Feb 1 2015

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Type 1 Diabetes Mellitus
C-Peptide
Insulin
Fasting
Body Weight
Multicenter Studies
Longitudinal Studies
Disease Progression
Insulin Resistance
Linear Models
Age Groups

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Medicine(all)

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BMI is an important driver of β-cell loss in type 1 diabetes upon diagnosis in 10 to 18-year-old children. / Lauria, A.; Barker, A.; Schloot, N.; Hosszúfalusi, N.; Ludvigsson, J.; Mathieu, C.; Mauricio, D.; Nordwall, M.; Van Der Schueren, B.; Mandrup-Poulsen, T.; Scherbaum, W. A.; Weets, I.; Gorus, F. K.; Wareham, N.; Leslie, R. D.; Pozzilli, P.

In: European Journal of Endocrinology, Vol. 172, No. 2, 01.02.2015, p. 107-113.

Research output: Contribution to journalArticle

Lauria, A, Barker, A, Schloot, N, Hosszúfalusi, N, Ludvigsson, J, Mathieu, C, Mauricio, D, Nordwall, M, Van Der Schueren, B, Mandrup-Poulsen, T, Scherbaum, WA, Weets, I, Gorus, FK, Wareham, N, Leslie, RD & Pozzilli, P 2015, 'BMI is an important driver of β-cell loss in type 1 diabetes upon diagnosis in 10 to 18-year-old children', European Journal of Endocrinology, vol. 172, no. 2, pp. 107-113. https://doi.org/10.1530/EJE-14-0522
Lauria, A. ; Barker, A. ; Schloot, N. ; Hosszúfalusi, N. ; Ludvigsson, J. ; Mathieu, C. ; Mauricio, D. ; Nordwall, M. ; Van Der Schueren, B. ; Mandrup-Poulsen, T. ; Scherbaum, W. A. ; Weets, I. ; Gorus, F. K. ; Wareham, N. ; Leslie, R. D. ; Pozzilli, P. / BMI is an important driver of β-cell loss in type 1 diabetes upon diagnosis in 10 to 18-year-old children. In: European Journal of Endocrinology. 2015 ; Vol. 172, No. 2. pp. 107-113.
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T1 - BMI is an important driver of β-cell loss in type 1 diabetes upon diagnosis in 10 to 18-year-old children

AU - Lauria, A.

AU - Barker, A.

AU - Schloot, N.

AU - Hosszúfalusi, N.

AU - Ludvigsson, J.

AU - Mathieu, C.

AU - Mauricio, D.

AU - Nordwall, M.

AU - Van Der Schueren, B.

AU - Mandrup-Poulsen, T.

AU - Scherbaum, W. A.

AU - Weets, I.

AU - Gorus, F. K.

AU - Wareham, N.

AU - Leslie, R. D.

AU - Pozzilli, P.

PY - 2015/2/1

Y1 - 2015/2/1

N2 - Objective: Body weight-related insulin resistance probably plays a role in progression to type 1 diabetes, but has an uncertain impact following diagnosis. In this study, we investigated whether BMI measured at diagnosis was an independent predictor of C-peptide decline 1-year post-diagnosis. Design: Multicentre longitudinal study carried out at diagnosis and up to 1-year follow-up. Methods: Data on C-peptide were collected from seven diabetes centres in Europe. Patients were grouped according to age at diagnosis (5 years 10 years 18 years, n=410). Linear regression was used to investigate whether BMI was an independent predictor of change in fasting C-peptide over 1 year. Models were additionally adjusted for baseline insulin dose and HbA1c. Results: In individuals diagnosed between 0 and 5 years, 5 and 10 years and those diagnosed >18 years, we found no association between BMI and C-peptide decline. In patients aged 10-18 years, higher BMI at baseline was associated with a greater decline in fasting C-peptide over 1 year with a decrease (β 95% CI; P value) of 0.025 (0.010, 0.041) nM/kg per m2 higher baseline BMI (P=0.001). This association remained significant after adjusting for gender and differences in HbA1c and insulin dose (β=0.026, 95% CI=0.0097, 0.042; P=0.002). Conclusions: These observations indicate that increased body weight and increased insulin demand are associated with more rapid disease progression after diagnosis of type 1 diabetes in an age group 10-18 years. This should be considered in studies of β-cell function in type 1 diabetes.

AB - Objective: Body weight-related insulin resistance probably plays a role in progression to type 1 diabetes, but has an uncertain impact following diagnosis. In this study, we investigated whether BMI measured at diagnosis was an independent predictor of C-peptide decline 1-year post-diagnosis. Design: Multicentre longitudinal study carried out at diagnosis and up to 1-year follow-up. Methods: Data on C-peptide were collected from seven diabetes centres in Europe. Patients were grouped according to age at diagnosis (5 years 10 years 18 years, n=410). Linear regression was used to investigate whether BMI was an independent predictor of change in fasting C-peptide over 1 year. Models were additionally adjusted for baseline insulin dose and HbA1c. Results: In individuals diagnosed between 0 and 5 years, 5 and 10 years and those diagnosed >18 years, we found no association between BMI and C-peptide decline. In patients aged 10-18 years, higher BMI at baseline was associated with a greater decline in fasting C-peptide over 1 year with a decrease (β 95% CI; P value) of 0.025 (0.010, 0.041) nM/kg per m2 higher baseline BMI (P=0.001). This association remained significant after adjusting for gender and differences in HbA1c and insulin dose (β=0.026, 95% CI=0.0097, 0.042; P=0.002). Conclusions: These observations indicate that increased body weight and increased insulin demand are associated with more rapid disease progression after diagnosis of type 1 diabetes in an age group 10-18 years. This should be considered in studies of β-cell function in type 1 diabetes.

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