Blunted leptin sensitivity during hedonic overeating can be reinstated by activating galanin 2 receptors (Gal2R) in the lateral hypothalamus

Este Leidmaa, Mary Gazea, Alexandre V. Patchev, Anna Pissioti, Nils Christian Gassen, Mayumi Kimura, Z. Liposits, I. Kalló, Osborne F.X. Almeida

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Aim: Since foods with high hedonic value are often consumed in excess of energetic needs, this study was designed to identify the mechanisms that may counter anorexigenic signalling in the presence of hedonic foods in lean animals. Methods: Mice, in different states of satiety (fed/fasted, or fed/fasted and treated with ghrelin or leptin, respectively), were allowed to choose between high-fat/high-sucrose and standard foods. Intake of each food type and the activity of hypothalamic neuropetidergic neurons that regulate appetite were monitored. In some cases, food choice was monitored in leptin-injected fasted mice that received microinjections of galanin receptor agonists into the lateral hypothalamus. Results: Appetite-stimulating orexin neurons in the lateral hypothalamus are rapidly activated when lean, satiated mice consume a highly palatable food (PF); such activation (upregulated c-Fos expression) occurred even after administration of the anorexigenic hormone leptin and despite intact leptin signalling in the hypothalamus. The ability of leptin to restrain PF eating is restored when a galanin receptor 2 (Gal2R) agonist is injected into the lateral hypothalamus. Conclusion: Hedonically-loaded foods interrupt the inhibitory actions of leptin on orexin neurons and interfere with the homeostatic control of feeding. Overeating of palatable foods can be curtailed in lean animals by activating Gal2R in the lateral hypothalamus.

Original languageEnglish
Article numbere13345
JournalActa Physiologica
DOIs
Publication statusPublished - Jan 1 2019

Fingerprint

Receptor, Galanin, Type 2
Lateral Hypothalamic Area
Hyperphagia
Pleasure
Leptin
Food
Appetite
Neurons
Galanin Receptors
Eating
Ghrelin
Aptitude
Microinjections
Hypothalamus
Sucrose
Fats

Keywords

  • galanin
  • ghrelin
  • lateral hypothalamus
  • leptin
  • orexin
  • overeating

ASJC Scopus subject areas

  • Physiology

Cite this

Leidmaa, E., Gazea, M., Patchev, A. V., Pissioti, A., Christian Gassen, N., Kimura, M., ... Almeida, O. F. X. (2019). Blunted leptin sensitivity during hedonic overeating can be reinstated by activating galanin 2 receptors (Gal2R) in the lateral hypothalamus. Acta Physiologica, [e13345]. https://doi.org/10.1111/apha.13345

Blunted leptin sensitivity during hedonic overeating can be reinstated by activating galanin 2 receptors (Gal2R) in the lateral hypothalamus. / Leidmaa, Este; Gazea, Mary; Patchev, Alexandre V.; Pissioti, Anna; Christian Gassen, Nils; Kimura, Mayumi; Liposits, Z.; Kalló, I.; Almeida, Osborne F.X.

In: Acta Physiologica, 01.01.2019.

Research output: Contribution to journalArticle

Leidmaa, Este ; Gazea, Mary ; Patchev, Alexandre V. ; Pissioti, Anna ; Christian Gassen, Nils ; Kimura, Mayumi ; Liposits, Z. ; Kalló, I. ; Almeida, Osborne F.X. / Blunted leptin sensitivity during hedonic overeating can be reinstated by activating galanin 2 receptors (Gal2R) in the lateral hypothalamus. In: Acta Physiologica. 2019.
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AU - Gazea, Mary

AU - Patchev, Alexandre V.

AU - Pissioti, Anna

AU - Christian Gassen, Nils

AU - Kimura, Mayumi

AU - Liposits, Z.

AU - Kalló, I.

AU - Almeida, Osborne F.X.

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AB - Aim: Since foods with high hedonic value are often consumed in excess of energetic needs, this study was designed to identify the mechanisms that may counter anorexigenic signalling in the presence of hedonic foods in lean animals. Methods: Mice, in different states of satiety (fed/fasted, or fed/fasted and treated with ghrelin or leptin, respectively), were allowed to choose between high-fat/high-sucrose and standard foods. Intake of each food type and the activity of hypothalamic neuropetidergic neurons that regulate appetite were monitored. In some cases, food choice was monitored in leptin-injected fasted mice that received microinjections of galanin receptor agonists into the lateral hypothalamus. Results: Appetite-stimulating orexin neurons in the lateral hypothalamus are rapidly activated when lean, satiated mice consume a highly palatable food (PF); such activation (upregulated c-Fos expression) occurred even after administration of the anorexigenic hormone leptin and despite intact leptin signalling in the hypothalamus. The ability of leptin to restrain PF eating is restored when a galanin receptor 2 (Gal2R) agonist is injected into the lateral hypothalamus. Conclusion: Hedonically-loaded foods interrupt the inhibitory actions of leptin on orexin neurons and interfere with the homeostatic control of feeding. Overeating of palatable foods can be curtailed in lean animals by activating Gal2R in the lateral hypothalamus.

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