Blood-Spot 17-Hydroxyprogesterone in Nonclassical 21-Hydroxylase Deficiency

Research output: Contribution to journalArticle

Abstract

The value of blood-spot 17-hydroxyprogesterone (17-OHP) measurements in selective screening for non-classical 21-hydroxylase deficiency (NC 21-OHD) among female patients with postnatal virilization was studied. Early morning basal blood-spot and serum samples, and post-ACTH serum samples for 17-OHP measurement were collected from twenty-seven patients with precocious pubarche, hirsutism and/or menstrual abnormalities (age: 3 to 17 years). Using a two-step extraction method for blood-spot 17-OHP measurements of all the nine patients with NC 21-OHD showed higher values than the eighteen patients without 21-OHD. Blood-spoot 17-OHP values of patients with NC 21-OHD showed a diurnal rhythm with pathological high levels between 0500 and 0900 h, and normal or slightly elevated levels between 1700 and 2100 h. In conclusion, early morning blood-spot 17-OHP measurement is a useful method to detect NC 21-OHD in the peripubertal period.

Original languageEnglish
Pages (from-to)295-299
Number of pages5
JournalExperimental and Clinical Endocrinology and Diabetes
Volume94
DOIs
Publication statusPublished - Jan 1989

Keywords

  • 17-Hydroxyprogesterone
  • Blood-spot
  • Congenital adrenal hyperplasia
  • Nonclassical 21-hydroxylase deficiency

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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