Blood glucose and plasma amino acid concentrations in infants of diabetic mothers

G. Soltész, K. Schultz, J. Mestyan, I. Horvath

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Postnatal blood glucose and individual plasma free amino acid levels were measured in 14 newborn infants of diabetic mothers. All infants had a significantly lower blood glucose concentration than normal controls but no significant correlation was observed between the blood glucose values and any of the amino acids determined. As regards the quantitative and qualitative changes of the plasma aminogram, the total concentration of amino acids and the level of a few individual amino acids (glycine, alanine, taurine, and valine) were significantly elevated in full-term babies. However, no significant difference was found in the total plasma concentration of amino acids between premature infants of diabetic mothers and premature control infants, but the plasma alanine level was higher in the former. It is of the interest that total plasma amino acid, alanine, and glycine levels were elevated in the asphyxiated babies. This suggests that the postnatal hyperaminoacidemia observed in infants of diabetic mothers was due to birth asphyxia rather than to impaired gluconeogenesis. The possible role of a defective gluconeogenesis in the etiology of postnatal hypoglycemia in infants of diabetic mothers is not supported by these data.

Original languageEnglish
Pages (from-to)77-82
Number of pages6
JournalPediatrics
Volume61
Issue number1
Publication statusPublished - 1978

Fingerprint

Blood Glucose
Mothers
Amino Acids
Alanine
Gluconeogenesis
Premature Infants
Glycine
Asphyxia
Taurine
Valine
Hypoglycemia
Parturition
Newborn Infant

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Blood glucose and plasma amino acid concentrations in infants of diabetic mothers. / Soltész, G.; Schultz, K.; Mestyan, J.; Horvath, I.

In: Pediatrics, Vol. 61, No. 1, 1978, p. 77-82.

Research output: Contribution to journalArticle

Soltész, G, Schultz, K, Mestyan, J & Horvath, I 1978, 'Blood glucose and plasma amino acid concentrations in infants of diabetic mothers', Pediatrics, vol. 61, no. 1, pp. 77-82.
Soltész, G. ; Schultz, K. ; Mestyan, J. ; Horvath, I. / Blood glucose and plasma amino acid concentrations in infants of diabetic mothers. In: Pediatrics. 1978 ; Vol. 61, No. 1. pp. 77-82.
@article{adc1f962bd6a449eaf34fb3fd8d425b7,
title = "Blood glucose and plasma amino acid concentrations in infants of diabetic mothers",
abstract = "Postnatal blood glucose and individual plasma free amino acid levels were measured in 14 newborn infants of diabetic mothers. All infants had a significantly lower blood glucose concentration than normal controls but no significant correlation was observed between the blood glucose values and any of the amino acids determined. As regards the quantitative and qualitative changes of the plasma aminogram, the total concentration of amino acids and the level of a few individual amino acids (glycine, alanine, taurine, and valine) were significantly elevated in full-term babies. However, no significant difference was found in the total plasma concentration of amino acids between premature infants of diabetic mothers and premature control infants, but the plasma alanine level was higher in the former. It is of the interest that total plasma amino acid, alanine, and glycine levels were elevated in the asphyxiated babies. This suggests that the postnatal hyperaminoacidemia observed in infants of diabetic mothers was due to birth asphyxia rather than to impaired gluconeogenesis. The possible role of a defective gluconeogenesis in the etiology of postnatal hypoglycemia in infants of diabetic mothers is not supported by these data.",
author = "G. Solt{\'e}sz and K. Schultz and J. Mestyan and I. Horvath",
year = "1978",
language = "English",
volume = "61",
pages = "77--82",
journal = "Pediatrics",
issn = "0031-4005",
publisher = "American Academy of Pediatrics",
number = "1",

}

TY - JOUR

T1 - Blood glucose and plasma amino acid concentrations in infants of diabetic mothers

AU - Soltész, G.

AU - Schultz, K.

AU - Mestyan, J.

AU - Horvath, I.

PY - 1978

Y1 - 1978

N2 - Postnatal blood glucose and individual plasma free amino acid levels were measured in 14 newborn infants of diabetic mothers. All infants had a significantly lower blood glucose concentration than normal controls but no significant correlation was observed between the blood glucose values and any of the amino acids determined. As regards the quantitative and qualitative changes of the plasma aminogram, the total concentration of amino acids and the level of a few individual amino acids (glycine, alanine, taurine, and valine) were significantly elevated in full-term babies. However, no significant difference was found in the total plasma concentration of amino acids between premature infants of diabetic mothers and premature control infants, but the plasma alanine level was higher in the former. It is of the interest that total plasma amino acid, alanine, and glycine levels were elevated in the asphyxiated babies. This suggests that the postnatal hyperaminoacidemia observed in infants of diabetic mothers was due to birth asphyxia rather than to impaired gluconeogenesis. The possible role of a defective gluconeogenesis in the etiology of postnatal hypoglycemia in infants of diabetic mothers is not supported by these data.

AB - Postnatal blood glucose and individual plasma free amino acid levels were measured in 14 newborn infants of diabetic mothers. All infants had a significantly lower blood glucose concentration than normal controls but no significant correlation was observed between the blood glucose values and any of the amino acids determined. As regards the quantitative and qualitative changes of the plasma aminogram, the total concentration of amino acids and the level of a few individual amino acids (glycine, alanine, taurine, and valine) were significantly elevated in full-term babies. However, no significant difference was found in the total plasma concentration of amino acids between premature infants of diabetic mothers and premature control infants, but the plasma alanine level was higher in the former. It is of the interest that total plasma amino acid, alanine, and glycine levels were elevated in the asphyxiated babies. This suggests that the postnatal hyperaminoacidemia observed in infants of diabetic mothers was due to birth asphyxia rather than to impaired gluconeogenesis. The possible role of a defective gluconeogenesis in the etiology of postnatal hypoglycemia in infants of diabetic mothers is not supported by these data.

UR - http://www.scopus.com/inward/record.url?scp=0017855825&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0017855825&partnerID=8YFLogxK

M3 - Article

C2 - 263878

AN - SCOPUS:0017855825

VL - 61

SP - 77

EP - 82

JO - Pediatrics

JF - Pediatrics

SN - 0031-4005

IS - 1

ER -