Die Blutströmung und PAH-Extraktion der isolierten Niere in der osmotischen Diurese und unter Ureterverschluß

Translated title of the contribution: Blood flow and p-aminohippurate extraction of the isolated kidney in osmotic diuresis and during ureter occlusion

L. Hársing, J. Bartha, T. Harza, G. Kövér

Research output: Contribution to journalArticle

Abstract

Experiments were performed on isolated perfused canine kidneys to investigate the renal circulation and PAH extraction in osmotic diuresis and during ureteral occlusion. Renal blood flow was measured simultaneously by venous outflow (direct RBF) and by86Rb method (86Rb-RBF) and renal regional blood flows on the basis of86Rb content of cortex, outer and inner medulla. During free urine flow the direct RBF attained 413 ml/min/100 g, the86Rb-RBF 310 ml/min/100 g, the ratio of cortical86Rb blood flow to total direct RBF 0.64 and EPAH 0.63, on the average. During stop flow the direct RBF decreased to 307 ml/min/100 g, the86Rb-RBF to 181 ml/min/100 g, the ratio of cortical86Rb blood flow to total direct RBF to 0.51 and EPAH to 0.52, on the average. The difference between the direct and the86Rb-RBF values with the adaequatly lower EPAH in the control is ascribed to the existance of AV-shunts in the isolated kidneys even in free flow of urine. While in the non isolated kidneys the elevated postcapillary vascular resistance during stop flow might be compensated by opening of AV-shunts, the lack of this compensatory mechanism in the isolated kidneys leads to the augmentation of total renal vascular resistance and the decrement of the capillary as well as the total RBF.

Original languageGerman
Pages (from-to)47-56
Number of pages10
JournalPflugers Archiv European Journal of Physiology
Volume308
Issue number1
DOIs
Publication statusPublished - Mar 1969

Fingerprint

p-Aminohippuric Acid
Diuresis
Ureter
Blood
Renal Circulation
Kidney
Vascular Resistance
Urine
Polycyclic aromatic hydrocarbons
Regional Blood Flow
Canidae
Experiments

Keywords

  • Isolated Kidney
  • RBF Determination by Rb-Method
  • Renal Circulation during Stop Flow
  • Ureter Occlusion

ASJC Scopus subject areas

  • Physiology

Cite this

Die Blutströmung und PAH-Extraktion der isolierten Niere in der osmotischen Diurese und unter Ureterverschluß. / Hársing, L.; Bartha, J.; Harza, T.; Kövér, G.

In: Pflugers Archiv European Journal of Physiology, Vol. 308, No. 1, 03.1969, p. 47-56.

Research output: Contribution to journalArticle

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