Blood fatty acid composition in relation to allergy in children aged 2-9 years: Results from the European IDEFICS study

A. Mikkelsen, C. Galli, G. Eiben, W. Ahrens, L. Iacoviello, D. Molnár, V. Pala, P. Risé, G. Rodriguez, P. Russo, M. Tornaritis, T. Veidebaum, K. Vyncke, M. Wolters, K. Mehlig

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background/objectives:Blood polyunsaturated fatty acids (PUFA) are involved in allergy development, but the etiological role of n-6 and n-3 PUFA is still controversial. A European multicenter study of children (IDEFICS) provided the opportunity to explore the cross-sectional association between fatty acids (FA) and allergy.Subjects/methods:Blood FA levels were measured in 2600 children aged 2-9 years and were recorded as the percentage of weight of all FA detected. Logistic regression of allergy status on FA components was adjusted for age, sex, country, body mass index, family history of allergic disease, breast-feeding, and number of siblings. The results were given as odds ratios (OR) for current vs no allergy ever and an increase in FA by 1 s.d.Results:Overall, higher proportions of n-6 PUFA were associated with higher odds of allergy (OR=1.21 (1.05, 1.40)). Monounsaturated FA (MUFA) were associated with reduced risk for allergy (OR=0.75 (0.65, 0.87)), whereas saturated FA did not differ by allergy status. The strongest associations were observed in children <4 years old, with ORs of allergy given as 1.62 (1.15, 2.29) for n-3 PUFA and 0.63 (0.42, 0.95) for MUFA. With regard to individual FA, these associations were independently observed for docosapentaenoic acid (22:5 n-3) and oleic acid (18:1 n-9).Conclusions:Both PUFA subtypes were positively associated with allergy in an age-dependent manner, whereas MUFA was associated with less allergy. The observation of high proportions of n-3 PUFA in allergic children younger than 4 years might help to understand the nature of early onset of atopic disease.

Original languageEnglish
Pages (from-to)39-44
Number of pages6
JournalEuropean Journal of Clinical Nutrition
Volume71
Issue number1
DOIs
Publication statusPublished - Jan 1 2017

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Hypersensitivity
Fatty Acids
Omega-3 Fatty Acids
Unsaturated Fatty Acids
Odds Ratio
Monounsaturated Fatty Acids
Oleic Acid
Breast Feeding
Multicenter Studies
Siblings
Body Mass Index
Logistic Models
Observation
Weights and Measures

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Blood fatty acid composition in relation to allergy in children aged 2-9 years : Results from the European IDEFICS study. / Mikkelsen, A.; Galli, C.; Eiben, G.; Ahrens, W.; Iacoviello, L.; Molnár, D.; Pala, V.; Risé, P.; Rodriguez, G.; Russo, P.; Tornaritis, M.; Veidebaum, T.; Vyncke, K.; Wolters, M.; Mehlig, K.

In: European Journal of Clinical Nutrition, Vol. 71, No. 1, 01.01.2017, p. 39-44.

Research output: Contribution to journalArticle

Mikkelsen, A, Galli, C, Eiben, G, Ahrens, W, Iacoviello, L, Molnár, D, Pala, V, Risé, P, Rodriguez, G, Russo, P, Tornaritis, M, Veidebaum, T, Vyncke, K, Wolters, M & Mehlig, K 2017, 'Blood fatty acid composition in relation to allergy in children aged 2-9 years: Results from the European IDEFICS study', European Journal of Clinical Nutrition, vol. 71, no. 1, pp. 39-44. https://doi.org/10.1038/ejcn.2016.158
Mikkelsen, A. ; Galli, C. ; Eiben, G. ; Ahrens, W. ; Iacoviello, L. ; Molnár, D. ; Pala, V. ; Risé, P. ; Rodriguez, G. ; Russo, P. ; Tornaritis, M. ; Veidebaum, T. ; Vyncke, K. ; Wolters, M. ; Mehlig, K. / Blood fatty acid composition in relation to allergy in children aged 2-9 years : Results from the European IDEFICS study. In: European Journal of Clinical Nutrition. 2017 ; Vol. 71, No. 1. pp. 39-44.
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abstract = "Background/objectives:Blood polyunsaturated fatty acids (PUFA) are involved in allergy development, but the etiological role of n-6 and n-3 PUFA is still controversial. A European multicenter study of children (IDEFICS) provided the opportunity to explore the cross-sectional association between fatty acids (FA) and allergy.Subjects/methods:Blood FA levels were measured in 2600 children aged 2-9 years and were recorded as the percentage of weight of all FA detected. Logistic regression of allergy status on FA components was adjusted for age, sex, country, body mass index, family history of allergic disease, breast-feeding, and number of siblings. The results were given as odds ratios (OR) for current vs no allergy ever and an increase in FA by 1 s.d.Results:Overall, higher proportions of n-6 PUFA were associated with higher odds of allergy (OR=1.21 (1.05, 1.40)). Monounsaturated FA (MUFA) were associated with reduced risk for allergy (OR=0.75 (0.65, 0.87)), whereas saturated FA did not differ by allergy status. The strongest associations were observed in children <4 years old, with ORs of allergy given as 1.62 (1.15, 2.29) for n-3 PUFA and 0.63 (0.42, 0.95) for MUFA. With regard to individual FA, these associations were independently observed for docosapentaenoic acid (22:5 n-3) and oleic acid (18:1 n-9).Conclusions:Both PUFA subtypes were positively associated with allergy in an age-dependent manner, whereas MUFA was associated with less allergy. The observation of high proportions of n-3 PUFA in allergic children younger than 4 years might help to understand the nature of early onset of atopic disease.",
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AU - Mikkelsen, A.

AU - Galli, C.

AU - Eiben, G.

AU - Ahrens, W.

AU - Iacoviello, L.

AU - Molnár, D.

AU - Pala, V.

AU - Risé, P.

AU - Rodriguez, G.

AU - Russo, P.

AU - Tornaritis, M.

AU - Veidebaum, T.

AU - Vyncke, K.

AU - Wolters, M.

AU - Mehlig, K.

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N2 - Background/objectives:Blood polyunsaturated fatty acids (PUFA) are involved in allergy development, but the etiological role of n-6 and n-3 PUFA is still controversial. A European multicenter study of children (IDEFICS) provided the opportunity to explore the cross-sectional association between fatty acids (FA) and allergy.Subjects/methods:Blood FA levels were measured in 2600 children aged 2-9 years and were recorded as the percentage of weight of all FA detected. Logistic regression of allergy status on FA components was adjusted for age, sex, country, body mass index, family history of allergic disease, breast-feeding, and number of siblings. The results were given as odds ratios (OR) for current vs no allergy ever and an increase in FA by 1 s.d.Results:Overall, higher proportions of n-6 PUFA were associated with higher odds of allergy (OR=1.21 (1.05, 1.40)). Monounsaturated FA (MUFA) were associated with reduced risk for allergy (OR=0.75 (0.65, 0.87)), whereas saturated FA did not differ by allergy status. The strongest associations were observed in children <4 years old, with ORs of allergy given as 1.62 (1.15, 2.29) for n-3 PUFA and 0.63 (0.42, 0.95) for MUFA. With regard to individual FA, these associations were independently observed for docosapentaenoic acid (22:5 n-3) and oleic acid (18:1 n-9).Conclusions:Both PUFA subtypes were positively associated with allergy in an age-dependent manner, whereas MUFA was associated with less allergy. The observation of high proportions of n-3 PUFA in allergic children younger than 4 years might help to understand the nature of early onset of atopic disease.

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