Blood-brain barrier co-culture models to study nanoparticle penetration

Focus on co-culture systems

S. Veszelka, Alexandra Bocsik, Fruzsina R. Walter, Dóra Hantosi, M. Deli

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

The blood-brain barrier, as a physical, active transport and metabolic barrier represents the main obstacle in the treatment of central nervous system diseases. The field of nanoparticle delivery systems is rapidly developing and nanocarriers seem to be promising for drug delivery or targeting to the brain. For testing the toxicity, uptake and transcellular transport of nanoparticles culture models of the blood-brain barrier are widely used, including immortalized brain endothelial cell lines, primary brain endothelial cells in static or dynamic culture conditions, and in co-culture systems with glial cells and/or pericytes. This mini-review gives a brief summary of blood-brain barrier co-culture models that were used for testing nanocarriers, the types of different nanoparticle systems that were examined on blood-brain barrier models, and the advantages, limitations and suitability of the blood-brain barrier models for nanoparticle penetration studies.

Original languageEnglish
Pages (from-to)157-168
Number of pages12
JournalActa Biologica Szegediensis
Volume59
Publication statusPublished - 2015

Fingerprint

blood-brain barrier
nanoparticles
coculture
Coculture Techniques
Blood-Brain Barrier
Nanoparticles
Brain
Endothelial cells
brain
endothelial cells
Endothelial Cells
Transcytosis
central nervous system diseases
Pericytes
active transport
Active Biological Transport
Central Nervous System Diseases
neuroglia
Neurology
Testing

Keywords

  • Blood-brain barrier
  • Brain delivery
  • Brain endothelial cells
  • Co-culture model
  • Drug targeting
  • Nanoparticle

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Blood-brain barrier co-culture models to study nanoparticle penetration : Focus on co-culture systems. / Veszelka, S.; Bocsik, Alexandra; Walter, Fruzsina R.; Hantosi, Dóra; Deli, M.

In: Acta Biologica Szegediensis, Vol. 59, 2015, p. 157-168.

Research output: Contribution to journalArticle

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