Blockers of volume-activated Cl- currents inhibit endothelial cell proliferation

Thomas Voets, Geza Szücs, Guy Droogmans, Bernd Nilius

Research output: Contribution to journalArticle

124 Citations (Scopus)

Abstract

Volume-activated Cl- currents (ICl,vol) and cell growth have been measured in cultured endothelial cells from bovine pulmonary artery (CPAE) in the absence and presence of compounds which block these currents. The anti-oestrogen drug tamoxifen, which efficiently arrests the growth of breast cancer cells (l), inhibits both ICl,vol and cell proliferation with IC50 of 3.8 and 4.8 μmol/l respectively. NPPB and quinine, which also block ICl,vol, inhibit the growth of CPAE cells as well. Current and cell growth were closely correlated under all these conditions. We conclude that ICl,vol might be involved in the control of endothelial cell growth and thus might be important for the modulation of vascularisation and vascular remodelling.

Original languageEnglish
Pages (from-to)132-134
Number of pages3
JournalPflügers Archiv European Journal of Physiology
Volume431
Issue number1
DOIs
Publication statusPublished - Nov 1 1995

Keywords

  • Cl currents
  • cell growth
  • endothelial cells
  • tamoxifen
  • volume-activated

ASJC Scopus subject areas

  • Physiology
  • Clinical Biochemistry
  • Physiology (medical)

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