Blockade of retrograde axoplasmic transport induces transganglionic degeneration atrophy of central terminals of primary nociceptive neurons

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

If applied locally around a peripheral sensory nerve, Formyl-Leurosin, a semi-synthetic diindol alkaloid of Vinca rosea - that, just like other mitotic spindle inhibitors, induces blockade of axoplasmic transport via inhibiting microtubular function - causes transganglionic degenerative atrophy of central terminals of primary nociceptive neurons in the substantia gelatinosa Rolandi of the spinal cord. In contrast, if applied to dorsal roots, Formyl-Leurosin fails to induce such alterations. Based upon these observations it is postulated that blockade of retrograde axoplasmic transport, rather than that of the orthograde one, is the decisive factor in the pathomechanism of transganglionic degenerative atrophy.

Original languageEnglish
Pages (from-to)149-156
Number of pages8
JournalActa Biologica Academiae Scientiarum Hungaricae
Volume33
Issue number2-3
Publication statusPublished - 1982

Fingerprint

Vinca Alkaloids
Nociceptors
Axonal Transport
alkaloid
atrophy
Neurons
Atrophy
inhibitor
neurons
Substantia Gelatinosa
Catharanthus
mitotic spindle apparatus
Spindle Apparatus
Catharanthus roseus
Spinal Nerve Roots
Peripheral Nerves
Alkaloids
spinal cord
alkaloids
Spinal Cord

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)

Cite this

@article{de967fcb083d45bd8ec6f7b00c6f1c05,
title = "Blockade of retrograde axoplasmic transport induces transganglionic degeneration atrophy of central terminals of primary nociceptive neurons",
abstract = "If applied locally around a peripheral sensory nerve, Formyl-Leurosin, a semi-synthetic diindol alkaloid of Vinca rosea - that, just like other mitotic spindle inhibitors, induces blockade of axoplasmic transport via inhibiting microtubular function - causes transganglionic degenerative atrophy of central terminals of primary nociceptive neurons in the substantia gelatinosa Rolandi of the spinal cord. In contrast, if applied to dorsal roots, Formyl-Leurosin fails to induce such alterations. Based upon these observations it is postulated that blockade of retrograde axoplasmic transport, rather than that of the orthograde one, is the decisive factor in the pathomechanism of transganglionic degenerative atrophy.",
author = "B. Csillik and E. Knyih{\'a}r-Csillik and J. Tajti",
year = "1982",
language = "English",
volume = "33",
pages = "149--156",
journal = "Acta Biologica Hungarica",
issn = "0236-5383",
publisher = "Akademiai Kiado",
number = "2-3",

}

TY - JOUR

T1 - Blockade of retrograde axoplasmic transport induces transganglionic degeneration atrophy of central terminals of primary nociceptive neurons

AU - Csillik, B.

AU - Knyihár-Csillik, E.

AU - Tajti, J.

PY - 1982

Y1 - 1982

N2 - If applied locally around a peripheral sensory nerve, Formyl-Leurosin, a semi-synthetic diindol alkaloid of Vinca rosea - that, just like other mitotic spindle inhibitors, induces blockade of axoplasmic transport via inhibiting microtubular function - causes transganglionic degenerative atrophy of central terminals of primary nociceptive neurons in the substantia gelatinosa Rolandi of the spinal cord. In contrast, if applied to dorsal roots, Formyl-Leurosin fails to induce such alterations. Based upon these observations it is postulated that blockade of retrograde axoplasmic transport, rather than that of the orthograde one, is the decisive factor in the pathomechanism of transganglionic degenerative atrophy.

AB - If applied locally around a peripheral sensory nerve, Formyl-Leurosin, a semi-synthetic diindol alkaloid of Vinca rosea - that, just like other mitotic spindle inhibitors, induces blockade of axoplasmic transport via inhibiting microtubular function - causes transganglionic degenerative atrophy of central terminals of primary nociceptive neurons in the substantia gelatinosa Rolandi of the spinal cord. In contrast, if applied to dorsal roots, Formyl-Leurosin fails to induce such alterations. Based upon these observations it is postulated that blockade of retrograde axoplasmic transport, rather than that of the orthograde one, is the decisive factor in the pathomechanism of transganglionic degenerative atrophy.

UR - http://www.scopus.com/inward/record.url?scp=0020409073&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0020409073&partnerID=8YFLogxK

M3 - Article

C2 - 6184919

AN - SCOPUS:0020409073

VL - 33

SP - 149

EP - 156

JO - Acta Biologica Hungarica

JF - Acta Biologica Hungarica

SN - 0236-5383

IS - 2-3

ER -