BLOCKADE OF ADRENALINE‐INDUCED HYPERGLYCAEMIA IN THE ANAESTHETIZED CAT BY CONTINUOUS INFUSION OF PHENTOLAMINE AND PROPRANOLOL

LAYLA M. AL‐JIBOURI, B. L. FURMAN, J. R. PARRATT

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The effects of adrenoceptor blocking drugs on the metabolic responses to adrenaline infusion (1 μg kg−1 min−1) have been studied in the anaesthetized, fasted cat. Propranolol, in doses (0.25 or 1 mg/kg) which prevented completely adrenaline‐induced tachycardia, reduced but did not abolish adrenaline‐induced hyperglycaemia. Phentolamine infusion, at a rate (15 μg kg−1 min−1 after a priming dose of 2.5 mg/kg) which reversed the pressor effect of adrenaline, reduced but did not abolish adrenaline‐induced hyperglycaemia. The continuous infusion of a combination of phentolamine (15 μg kg−1 min−1 after a priming dose of 2.5 mg/kg) and propranolol (5 μg kg−1 min−1 after a priming dose of 0.25 mg/kg) prevented completely the hyperglycaemia response to adrenaline infusion over a 6 h period. The increase in blood lactate concentration produced by adrenaline was prevented completely by the combined infusion of propranolol and phentolamine but was not modified by phentolamine alone. 1980 British Pharmacological Society

Original languageEnglish
Pages (from-to)461-466
Number of pages6
JournalBritish journal of pharmacology
Volume68
Issue number3
DOIs
Publication statusPublished - Mar 1980

ASJC Scopus subject areas

  • Pharmacology

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